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Study Data from Humanitas Cancer Center Update Understanding of Small Cell Lung Cancer [Volumetric modulated arc therapy with flattening filter free...

July 23, 2014



Study Data from Humanitas Cancer Center Update Understanding of Small Cell Lung Cancer [Volumetric modulated arc therapy with flattening filter free (FFF) beams for stereotactic body radiation therapy (SBRT) in patients with medically inoperable ...]

By a News Reporter-Staff News Editor at Biotech Week -- Investigators discuss new findings in Lung Diseases and Conditions. According to news reporting out of Milan, Italy, by NewsRx editors, research stated, "To assess the impact of volumetric modulated arc therapy (VMAT) with flattening filter free (FFF) beams for stereotactic body radiotherapy (SBRT) in inoperable stage I NSCLC. Current data were compared against a cohort of patients previously treated with advanced conformal techniques (3DCRT) based on conformal arcs."

Our news journalists obtained a quote from the research from Humanitas Cancer Center, "From July 2006 to December 2011 132 patients underwent SBRT, 86 by 3DCRT with flattened beams (FF), while the last 46 with VMAT RapidArc and unflattened beams (FFF). All patients were treated with 48 Gy in four fractions of 12 Gy each. Patients underwent follow-up. Clinical outcome was evaluated with thoracic and abdominal CT scan and 18FDG-CTPET before and after treatment. Both techniques achieved adequate dose conformity to the target but with a statistically significant reduction of ipsilateral lung doses in RapidArc plans and also of Beam-on-Time (BOT) with FFF mode. The median follow up was 16 months (range 2-24 months). At 1 year, local control rate was 100% with FFF beams compared with 92.5% with FF beams (p=0.03)."

According to the news editors, the research concluded: "SBRT with FFF beams permitted us a safe delivery of high dose per fraction in a short treatment time and resulted in an earlier radiological response compared with FF beams."

For more information on this research see: Volumetric modulated arc therapy with flattening filter free (FFF) beams for stereotactic body radiation therapy (SBRT) in patients with medically inoperable early stage non small cell lung cancer (NSCLC). Radiotherapy and Oncology, 2013;107(3):414-8. (Elsevier - www.elsevier.com; Radiotherapy and Oncology - www.elsevier.com/wps/product/cws_home/506042)

Our news journalists report that additional information may be obtained by contacting P. Navarria, Radiotherapy and Radiosurgery Department, Humanitas Cancer Center, Istituto Clinico Humanitas, Milan, Italy. Additional authors for this research include A.M. Ascolese, P. Mancosu, F. Alongi, E. Clerici, A. Tozzi, C. Iftode, G. Reggiori, S. Tomatis, M. Infante, M. Alloisio, A. Testori, A. Fogliata, L. Cozzi, E. Morenghi and M. Scorsetti (see also Lung Diseases and Conditions).

Keywords for this news article include: Milan, Italy, Europe, Oncology, Lung Neoplasms, Radiation Therapy, Small Cell Lung Cancer, Lung Diseases and Conditions.

Our reports deliver fact-based news of research and discoveries from around the world. Copyright 2014, NewsRx LLC


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Source: Biotech Week


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