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Studies from University of Auckland Further Understanding of Bone Research (A multi-scale structural study of the porcine anterior cruciate ligament...

July 25, 2014



Studies from University of Auckland Further Understanding of Bone Research (A multi-scale structural study of the porcine anterior cruciate ligament tibial enthesis)

By a News Reporter-Staff News Editor at Health & Medicine Week -- Researchers detail new data in Bone Research. According to news reporting originating in Auckland, New Zealand, by NewsRx journalists, research stated, "Like the human anterior cruciate ligament (ACL), the porcine ACL also has a double bundle structure and several biomechanical studies using this model have been carried out to show the differential effect of these two bundles on macro-level knee joint function. It is hypothesised that if the different bundles of the porcine ACL are mechanically distinct in function, then a multi-scale anatomical characterisation of their individual enthesis will also reveal significant differences in structure between the bundles."

The news reporters obtained a quote from the research from the University of Auckland, "Twenty-two porcine knee joints were cleared of their musculature to expose the intact ACL following which ligament-bone samples were obtained. The samples were fixed in formalin followed by decalcification with formic acid. Thin sections containing the ligament insertion into the tibia were then obtained by cryosectioning and analysed using differential interference contrast (DIC) optical microscopy and scanning electron microscopy (SEM). At the micro-level, the anteromedial (AM) bundle insertion at the tibia displayed a significant deep-rooted interdigitation into bone, while for the posterolateral (PL) bundle the fibre insertions were less distributed and more focal. Three sub-types of enthesis were identified in the ACL and related to (i) bundle type, (ii) positional aspect within the insertion, and (iii) specific bundle function. At the nano-level the fibrils of the AM bundle were significantly larger than those in the PL bundle. The modes by which the AM and PL fibrils merged with the bone matrix fibrils were significantly different."

According to the news reporters, the research concluded: "A biomechanical interpretation of the data suggests that the porcine ACL enthesis is a specialized, functionally graded structural continuum, adapted at the micro-to-nano scales to serve joint function at the macro level."

For more information on this research see: A multi-scale structural study of the porcine anterior cruciate ligament tibial enthesis. Journal of Anatomy, 2014;224(6):624-633. Journal of Anatomy can be contacted at: Wiley-Blackwell, 111 River St, Hoboken 07030-5774, NJ, USA. (Wiley-Blackwell - www.wiley.com/; Journal of Anatomy - onlinelibrary.wiley.com/journal/10.1111/(ISSN)1469-7580)

Our news correspondents report that additional information may be obtained by contacting L. Zhao, University of Auckland, Dept. of Chem & Mat Engn, Auckland 1142, New Zealand. Additional authors for this research include A. Thambyah and N.D. Broom (see also Bone Research).

Keywords for this news article include: Auckland, Bone Research, Australia and New Zealand

Our reports deliver fact-based news of research and discoveries from around the world. Copyright 2014, NewsRx LLC


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Source: Health & Medicine Week


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