News Column

Studies from Peking Union Medical College Have Provided New Information about Hepatocellular Cancer (TAT-LHRH conjugated low molecular weight...

July 22, 2014



Studies from Peking Union Medical College Have Provided New Information about Hepatocellular Cancer (TAT-LHRH conjugated low molecular weight chitosan as a gene carrier specific for hepatocellular carcinoma cells)

By a News Reporter-Staff News Editor at Cancer Weekly -- New research on Oncology is the subject of a report. According to news reporting originating from Tianjin, People's Republic of China, by NewsRx correspondents, research stated, "To develop a chitosan-based nonviral gene carrier capable of delivering genes specifically into hepatoma cells, a bifunctional peptide composed of the TAT (transactivator of transcription) peptide and luteinizing hormone-releasing hormone (LHRH) was conjugated with low molecular weight chitosan, resulting in a TAT-LHRH-chitosan conjugate (TLC). TLC/DNA nanoparticles (TLCDNPs) were characterized by agarose gel retardation, atomic force microscopy, and dynamic light scattering analysis."

Our news editors obtained a quote from the research from Peking Union Medical College, "In vitro targeting specificity and transfection efficiency were analyzed with a GE IN Cell Analyzer 2000 High-Content Cellular Analysis System. The results demonstrated that TLC had stronger DNA condensing power than unmodified chitosan, and that TLCDNPs were of roughly round shape with average diameter of 70-85 nm and zeta potential of +30 mV and were relatively stable in solution."

According to the news editors, the research concluded: "The in vitro study demonstrated TLC was highly selective for hepatoma cells and essentially nontoxic."

For more information on this research see: TAT-LHRH conjugated low molecular weight chitosan as a gene carrier specific for hepatocellular carcinoma cells. International Journal of Nanomedicine, 2014;9():2879-2889. International Journal of Nanomedicine can be contacted at: Dove Medical Press Ltd, PO Box 300-008, Albany, Auckland 0752, New Zealand (see also Oncology).

The news editors report that additional information may be obtained by contacting L.X. Liu, Peking Union Med College, Tianjin Key Lab Biomed Mat, Tianjin, People's Republic of China. Additional authors for this research include X. Dong, D.W. Zhu, L.P. Song, H.L. Zhang and X.G.G. Leng.

Keywords for this news article include: Asia, Tianjin, Genetics, Hormones, Oncology, Hepatocellular Carcinoma, People's Republic of China

Our reports deliver fact-based news of research and discoveries from around the world. Copyright 2014, NewsRx LLC


For more stories covering the world of technology, please see HispanicBusiness' Tech Channel



Source: Cancer Weekly


Story Tools






HispanicBusiness.com Facebook Linkedin Twitter RSS Feed Email Alerts & Newsletters