News Column

Studies from Harvard University in the Area of Biochemistry Reported (Platinum Compounds for High-Resolution In Vivo Cancer Imaging)

July 23, 2014

By a News Reporter-Staff News Editor at Biotech Week -- Current study results on Life Science Research have been published. According to news reporting out of Boston, Massachusetts, by NewsRx editors, research stated, "Platinum(II) compounds, principally cisplatin and carboplatin, are commonly used front-line cancer therapeutics. Despite their widespread use and continued interest in the development of new derivatives, including nanoformulations with improved properties, it has been difficult to visualize platinum compounds in live subjects, in real time, and with subcellular resolution."

Our news journalists obtained a quote from the research from Harvard University, "Here, we present four novel cisplatin- and carboplatin-derived fluorescent imaging compounds for quantitative intravital cancer imaging. We conjugated 4,4-difluoro-5,7-dimethyl-4-bora-3a,4a-daiza-s-indacene (BODIPY) to PtII complexes to generate derivatives with robust in vivo fluorescence and retained DNA-damaging and cytotoxic properties. We successfully applied these compounds to image pharmacokinetics and tumor uptake in a xenograft cancer mouse model. By using a genetic reporter of single-cell DNA damage for in vivo imaging, Pt drug accumulation and resultant DNA damage could be monitored in individual tumor cells, at subcellular resolution, and in real time in a live animal model of cancer."

According to the news editors, the research concluded: "These derivatives represent promising imaging tools that will be useful in understanding further the distribution and interactions of platinum within tumors."

For more information on this research see: Platinum Compounds for High-Resolution In Vivo Cancer Imaging. Chemmedchem, 2014;9(6):1131-1135. Chemmedchem can be contacted at: Wiley-V C H Verlag Gmbh, Boschstrasse 12, D-69469 Weinheim, Germany. (Wiley-Blackwell -; Chemmedchem -

Our news journalists report that additional information may be obtained by contacting M.A. Miller, Harvard University, Sch Med, Dept. of Syst Biol, Boston, MA 02115, United States. Additional authors for this research include B. Askevold, K.S. Yang, R.H. Kohler and R. Weissleder (see also Life Science Research).

Keywords for this news article include: Boston, Cancer, Genetics, Oncology, Massachusetts, United States, Life Science Research, North and Central America

Our reports deliver fact-based news of research and discoveries from around the world. Copyright 2014, NewsRx LLC

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Source: Biotech Week

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