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Studies from Amrita University in the Area of Antibiotics Described (Tetracycline nanoparticles loaded calcium sulfate composite beads for...

July 23, 2014



Studies from Amrita University in the Area of Antibiotics Described (Tetracycline nanoparticles loaded calcium sulfate composite beads for periodontal management)

By a News Reporter-Staff News Editor at Biotech Week -- Investigators publish new report on Drugs and Therapies. According to news originating from Kochi, India, by NewsRx correspondents, research stated, "The objective of this study was to fabricate, characterize and evaluate in vitro, an injectable calcium sulfate bone cement beads loaded with an antibiotic nanoformulation, capable of delivering antibiotic locally for the treatment of periodontal disease. Tetracycline nanoparticles (Tet NPs) were prepared using an ionic gelation method and characterized using DLS, SEM, and FTIR to determine size, morphology, stability and chemical interaction of the drug with the polymer."

Our news journalists obtained a quote from the research from Amrita University, "Further, calcium sulfate (CaSO4) control and CaSO4-Tet NP composite beads were prepared and characterized using SEM, FTIR and XRD. The drug release pattern, material properties and antibacterial activity were evaluated. In addition, protein adsorption, cytocompatibility and alkaline phosphatase activity of the CaSO4-Tet NP composite beads in comparison to the CaSO4 control were analyzed. Tet NPs showed a size range of 13020nm and the entrapment efficiency calculated was 89%. The composite beads showed sustained drug release pattern. Further the drug release data was fitted into various kinetic models wherein the Higuchi model showed higher correlation value (R(2)=0.9279) as compared to other kinetic models. The composite beads showed antibacterial activity against Staphylococcus aureus and Escherichia coli. The presence of Tet NPs in the composite bead didn't alter its cytocompatibility. In addition, the composite beads enhanced the ALP activity of hPDL cells. The antibacterial and cytocompatible CaSO4-Tet NP composite beads could be beneficial in periodontal management to reduce the bacterial load at the infection site."

According to the news editors, the research concluded: "Tet NPs would deliver antibiotic locally at the infection site and the calcium sulfate cement, would itself facilitate tissue regeneration."

For more information on this research see: Tetracycline nanoparticles loaded calcium sulfate composite beads for periodontal management. Biochimica Et Biophysica Acta, 2014;1840(6):2080-90 (see also Drugs and Therapies).

The news correspondents report that additional information may be obtained from N. Sindhura Reddy, Amrita Centre for Nanosciences and Molecular Medicine, Amrita Institute of Medical Sciences and Research Centre, Amrita Vishwa Vidyapeetham University, Kochi 682041, India. Additional authors for this research include S. Sowmya, J.D. Bumgardner, K.P. Chennazhi, R. Biswas and R. Jayakumar.

Keywords for this news article include: Asia, Antibacterial, Antibiotics, Antimicrobials, Kochi, India, Minerals, Chemistry, Hydrocarbons, Nanoparticle, Naphthacenes, Sulfur Acids, Tetracyclines, Nanotechnology, Calcium Sulfate, Sulfur Compounds, Calcium Compounds, Drugs and Therapies, Inorganic Chemicals, Emerging Technologies.

Our reports deliver fact-based news of research and discoveries from around the world. Copyright 2014, NewsRx LLC


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Source: Biotech Week


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