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Shanghai Jiao-Tong University Reports Findings in Gastroenterology (SiO2 nanoparticle-induced impairment of mitochondrial energy metabolism in...

July 21, 2014



Shanghai Jiao-Tong University Reports Findings in Gastroenterology (SiO2 nanoparticle-induced impairment of mitochondrial energy metabolism in hepatocytes directly and through a Kupffer cell-mediated pathway in vitro)

By a News Reporter-Staff News Editor at Gastroenterology Week -- Investigators publish new report on Gastroenterology. According to news reporting originating in Shanghai, People's Republic of China, by NewsRx journalists, research stated, "The liver has been shown to be a primary target organ for SiO2 nanoparticles in vivo, and may be highly susceptible to damage by these nanoparticles. However, until now, research focusing on the potential toxic effects of SiO2 nanoparticles on mitochondria-associated energy metabolism in hepatocytes has been lacking."

The news reporters obtained a quote from the research from Shanghai Jiao-Tong University, "In this work, SiO2 nanoparticles 20 nm in diameter were evaluated for their ability to induce dysfunction of mitochondrial energy metabolism. First, a buffalo rat liver (BRL) cell line was directly exposed to SiO2 nanoparticles, which induced cytotoxicity and mitochondrial damage accompanied by decreases in mitochondrial dehydrogenase activity, mitochondrial membrane potential, enzymatic expression in the Krebs cycle, and activity of the mitochondrial respiratory chain complexes I, III and IV. Second, the role of rat-derived Kupffer cells was evaluated. The supernatants from Kupffer cells treated with SiO2 nanoparticles were transferred to stimulate BRL cells."

According to the news reporters, the research concluded: "We observed that SiO2 nanoparticles had the ability to activate Kupffer cells, leading to release of tumor necrosis factor-alpha, nitric oxide, and reactive oxygen species from these cells and subsequently to - inhibition of mitochondrial respiratory chain complex I activity in BRL cells."

For more information on this research see: SiO2 nanoparticle-induced impairment of mitochondrial energy metabolism in hepatocytes directly and through a Kupffer cell-mediated pathway in vitro. International Journal of Nanomedicine, 2014;9():2891-2903. International Journal of Nanomedicine can be contacted at: Dove Medical Press Ltd, PO Box 300-008, Albany, Auckland 0752, New Zealand (see also Gastroenterology).

Our news correspondents report that additional information may be obtained by contacting Y. Xue, Shanghai Jiao Tong University, Sch Med, Peoples Hosp 9, Shanghai Biomat Res & Testing CenterShanghai Key La, Shanghai 200023, People's Republic of China. Additional authors for this research include Q.Q. Chen, T.T. Ding and J. Sun.

Keywords for this news article include: Asia, Shanghai, Immunology, Hepatocytes, Macrophages, Nanoparticle, Kupffer Cells, Nanotechnology, Gastroenterology, Emerging Technologies, Hemic and Immune Systems, People's Republic of China

Our reports deliver fact-based news of research and discoveries from around the world. Copyright 2014, NewsRx LLC


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Source: Gastroenterology Week


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