News Column

Researchers from University of Mumbai Detail Findings in Nanoparticles (Bioactivity of albumins bound to silver nanoparticles)

July 23, 2014

By a News Reporter-Staff News Editor at Biotech Week -- Current study results on Nanoparticles have been published. According to news reporting originating in Mumbai, India, by NewsRx journalists, research stated, "The last decade has witnessed a tremendous rise in the proposed applications of nanomaterials in the field of medicine due to their very attractive physiochemical properties and novel actions such as the ability to reach previously inaccessible targets such as brain. However biological activity of functional molecules bound to nanoparticles and its physiological consequences is still unclear and hence this area requires immediate attention."

The news reporters obtained a quote from the research from the University of Mumbai, "The functional properties of Human Serum Albumin (HSA) and Bovine Serum Albumin (BSA) bound to silver nanoparticles (~60 nm) have been studied under physiological environment. Esterase activity, binding of drugs (warfarin and ibuprofen), antioxidant activity and copper binding by albumins was evaluated. The catalytic efficiencies of HSA and BSA diminished upon binding to silver nanoparticles. Perturbation in binding of warfarin and ibuprofen, loss of free sulphydryls, antioxidant activity and enhancement of copper binding were observed in albumins bound to nanoparticles."

According to the news reporters, the research concluded: "These alterations in functional activity of nanoparticle bound albumins which will have important consequences should be taken into consideration while using nanoparticles for diagnostic and therapeutic purposes."

For more information on this research see: Bioactivity of albumins bound to silver nanoparticles. The Protein Journal, 2014;33(3):258-66. The Protein Journal can be contacted at: Springer, 233 Spring Street, New York, NY 10013, USA (see also Nanoparticles).

Our news correspondents report that additional information may be obtained by contacting J. Mariam, Dept. of Biophysics, University of Mumbai, Vidyanagari, Santacruz (E), Mumbai, 400 098, India. Additional authors for this research include S. Sivakami, D.C. Kothari and P.M Dongre.

The publisher of the The Protein Journal can be contacted at: Springer, 233 Spring Street, New York, NY 10013, USA.

Keywords for this news article include: Asia, India, Mumbai, Nanotechnology, Emerging Technologies.

Our reports deliver fact-based news of research and discoveries from around the world. Copyright 2014, NewsRx LLC

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Source: Biotech Week

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