Our news editors obtained a quote from the research from the School of Medicine, "Several different variants of NKG2D-based chimeric antigen receptors (CARs) have been developed, and extensive in vivo mechanistic studies performed demonstrated that cytotoxicity and cytokines are important for the efficacy NKG2D CAR adoptive T-cell therapy. NKG2D CARs target tumor cells, and they also target immunosuppressive cells within the tumor microenvironment. Under certain conditions, NKG2D ligand expression can be found on nontumor tissue, so potential off-tumor toxicity remains."
According to the news editors, the research concluded: "In this article, we review the use of NKG2D as a basis for CAR targeting of tumors."
For more information on this research see: NKG2D CARs as Cell Therapy for Cancer.
The news editors report that additional information may be obtained by contacting
Keywords for this news article include: Biotechnology, Biomedicine, Cancer,
Our reports deliver fact-based news of research and discoveries from around the world. Copyright 2014, NewsRx LLC
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