News Column

Researchers from School of Medicine Report on Findings in Cell Therapy (NKG2D CARs as Cell Therapy for Cancer)

July 22, 2014



By a News Reporter-Staff News Editor at Cancer Weekly -- Research findings on Biomedicine are discussed in a new report. According to news reporting originating from Lebanon, New Hampshire, by NewsRx correspondents, research stated, "The NKG2D cell receptor and its ligands have attracted considerable interest as a potential strategy to attack tumor cells. NKG2D ligands are expressed on most types of tumors, and they demonstrate relative selectivity of ligand expression on tumor cells compared to healthy cells."

Our news editors obtained a quote from the research from the School of Medicine, "Several different variants of NKG2D-based chimeric antigen receptors (CARs) have been developed, and extensive in vivo mechanistic studies performed demonstrated that cytotoxicity and cytokines are important for the efficacy NKG2D CAR adoptive T-cell therapy. NKG2D CARs target tumor cells, and they also target immunosuppressive cells within the tumor microenvironment. Under certain conditions, NKG2D ligand expression can be found on nontumor tissue, so potential off-tumor toxicity remains."

According to the news editors, the research concluded: "In this article, we review the use of NKG2D as a basis for CAR targeting of tumors."

For more information on this research see: NKG2D CARs as Cell Therapy for Cancer. Cancer Journal, 2014;20(2):156-159. Cancer Journal can be contacted at: Lippincott Williams & Wilkins, 530 Walnut St, Philadelphia, PA 19106-3621, USA (see also Biomedicine).

The news editors report that additional information may be obtained by contacting C.L. Sentman, Geisel Sch Med Dartmouth, Dept. of Med, Sect Hematol & Oncol, Lebanon, NH 03756, United States.

Keywords for this news article include: Biotechnology, Biomedicine, Cancer, Lebanon, Oncology, Cell Therapy, New Hampshire, United States, Biological Therapy, North and Central America

Our reports deliver fact-based news of research and discoveries from around the world. Copyright 2014, NewsRx LLC


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Source: Cancer Weekly


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