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Researchers from Boston University Report New Studies and Findings in the Area of Breast Cancer (In vitro activity of Paclitaxel-loaded polymeric...

July 24, 2014



Researchers from Boston University Report New Studies and Findings in the Area of Breast Cancer (In vitro activity of Paclitaxel-loaded polymeric expansile nanoparticles in breast cancer cells)

By a News Reporter-Staff News Editor at Women's Health Weekly -- A new study on Oncology is now available. According to news reporting originating from Boston, Massachusetts, by NewsRx correspondents, research stated, "Through a series of in vitro studies, the essential steps for intracellular drug delivery of paclitaxel using a pH-responsive nanoparticle system have been investigated in breast cancer cells. We successfully encapsulated paclitaxel within polymeric expansile nanoparticles (Pax-eNPs) at 5% loading via a miniemulsion polymerization procedure."

Our news editors obtained a quote from the research from Boston University, "Fluorescently tagged eNPs were readily taken up by MDA-MB-231 breast cancer cells grown in culture as confirmed by confocal microscopy and flow cytometry. The ability of the encapsulated paclitaxel to reach the cytoplasm was also observed using confocal microscopy and fluorescently labeled paclitaxel. Pax-eNPs were shown to be efficacious against three in vitro human breast adenocarcinoma cell lines (MDA-MB-231, MCF-7, and SK-BR-3) as well as cells isolated from the pleural effusions of two different breast cancer patients."

According to the news editors, the research concluded: "Lastly, macropinocytosis was identified as the major cellular pathway responsible for eNP uptake, as confirmed using temperature-sensitive metabolic reduction, pharmacologic inhibitors, and fluid-phase marker colocalization."

For more information on this research see: In vitro activity of Paclitaxel-loaded polymeric expansile nanoparticles in breast cancer cells. Biomacromolecules, 2013;14(6):2074-82. (American Chemical Society - www.acs.org; Biomacromolecules - www.pubs.acs.org/journal/bomaf6)

The news editors report that additional information may be obtained by contacting K.A. Zubris, Departments of Biomedical Engineering and Chemistry, Boston University , Boston, Massachusetts 02215, United States. Additional authors for this research include R. Liu, A. Colby, M.D. Schulz, Y.L. Colson and M.W Grinstaff (see also Oncology).

Keywords for this news article include: Antineoplastics, Pharmaceuticals, Drugs, Boston, Taxoids, Therapy, Oncology, Terpenes, Paclitaxel, Hydrocarbons, Nanoparticle, Massachusetts, United States, Breast Cancer, Cycloparaffins, Nanotechnology, Women's Health, Organic Chemicals, Mitotic Inhibitors, Emerging Technologies, North and Central America.

Our reports deliver fact-based news of research and discoveries from around the world. Copyright 2014, NewsRx LLC


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Source: Women's Health Weekly


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