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Researchers at Rosalind Franklin University of Medicine and Science Report New Data on Stem Cells (Prospects for Engineering Neurons From Local...

July 21, 2014



Researchers at Rosalind Franklin University of Medicine and Science Report New Data on Stem Cells (Prospects for Engineering Neurons From Local Neocortical Cell Populations as Cell-Mediated Therapy for Neurological Disorders)

By a News Reporter-Staff News Editor at Stem Cell Week -- Investigators publish new report on Stem Cell Research. According to news reporting originating from North Chicago, Illinois, by NewsRx correspondents, research stated, "There is little cell replacement following neurological injury, limiting the regenerative response of the CNS. Progress in understanding the biology of neural stem cells has raised interest in using stem cells for replacing neurons lost to injury or to disease."

Our news editors obtained a quote from the research from the Rosalind Franklin University of Medicine and Science, "Stem cell therapy may also have a role in rebuilding deficient neural circuitry underlying mood disorders, epilepsy, and pain modulation among other roles. In vitro expansion of stem cells with directed differentiation prior to transplantation is one approach to stem cell therapy. Emerging evidence suggests that it may be possible to convert in vivo endogenous neural cells to a neuronal fate directly, providing an alternative strategy for stem cell therapy to the CNS. This review assesses the evidence for engineering a subtype-specific neuronal fate of endogenous neural cells in the cerebral cortex as a function of initial cell lineage, reactive response to injury, conversion factors, and environmental context."

According to the news editors, the research concluded: "We conclude with a discussion of some of the challenges that must be overcome to move this alternative in vivo engineered conversion process toward becoming a viable therapeutic option."

For more information on this research see: Prospects for Engineering Neurons From Local Neocortical Cell Populations as Cell-Mediated Therapy for Neurological Disorders. Journal of Comparative Neurology, 2014;522(12):2857-2876. Journal of Comparative Neurology can be contacted at: Wiley-Blackwell, 111 River St, Hoboken 07030-5774, NJ, USA. (Wiley-Blackwell - www.wiley.com/; Journal of Comparative Neurology - onlinelibrary.wiley.com/journal/10.1002/(ISSN)1096-9861)

The news editors report that additional information may be obtained by contacting S. Bazarek, Rosalind Franklin Univ Med & Sci, Center Stem Cell & Regenerat Med, Chicago Med Sch, Dept. of Neurosci, North Chicago, IL 60064, United States (see also Stem Cell Research).

Keywords for this news article include: Neurons, Therapy, Illinois, North Chicago, United States, Stem Cell Research, North and Central America

Our reports deliver fact-based news of research and discoveries from around the world. Copyright 2014, NewsRx LLC


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Source: Stem Cell Week


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