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Researchers at Rensselaer Polytechnic Institute Report Findings in Escherichia coli [Effect of eliminase gene (elmA) deletion on heparosan production...

July 23, 2014



Researchers at Rensselaer Polytechnic Institute Report Findings in Escherichia coli [Effect of eliminase gene (elmA) deletion on heparosan production and shedding in Escherichia coli K5]

By a News Reporter-Staff News Editor at Biotech Week -- Fresh data on Proteobacteria are presented in a new report. According to news reporting from Troy, New York, by NewsRx journalists, research stated, "Escherichia coli K5 produces heparosan and sheds it into the growth medium in a temperature dependent manner. The shedding is believed to be controlled, at least in part, by enzyme action on the cell-associated capsular polysaccharide, heparosan."

The news correspondents obtained a quote from the research from Rensselaer Polytechnic Institute, "One candidate enzyme in such shedding is eliminase. The eliminase gene (elmA) was deleted from the genome of E. coli K5 and its effect on secreted and cell-associated heparosan was investigated."

According to the news reporters, the research concluded: "Deletion of the eliminase gene resulted in a significant reduction in heparosan shedding into the medium and heparosan content in the capsule of the cells, indicating its pivotal role in heparosan synthesis and shedding by E."

For more information on this research see: Effect of eliminase gene (elmA) deletion on heparosan production and shedding in Escherichia coli K5. Journal of Biotechnology, 2013;165(3-4):175-7. (Elsevier - www.elsevier.com; Journal of Biotechnology - www.elsevier.com/wps/product/cws_home/505515)

Our news journalists report that additional information may be obtained by contacting A.M. Hickey, Center for Biotechnology and Interdisciplinary Studies, Rensselaer Polytechnic Institute, Troy, NY 12180, United States. Additional authors for this research include U. Bhaskar, R.J. Linhardt and J.S Dordick (see also Proteobacteria).

Keywords for this news article include: Troy, New York, United States, Proteobacteria, Escherichia coli, Enterobacteriaceae, Gram Negative Bacteria, North and Central America.

Our reports deliver fact-based news of research and discoveries from around the world. Copyright 2014, NewsRx LLC


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Source: Biotech Week


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