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Researchers at National Institute of Criminalistics and Criminology Release New Data on Analytical Toxicology (Validation of an automated solid-phase...

July 25, 2014



Researchers at National Institute of Criminalistics and Criminology Release New Data on Analytical Toxicology (Validation of an automated solid-phase extraction method for the analysis of 23 opioids, cocaine, and metabolites in urine with ...)

By a News Reporter-Staff News Editor at Health & Medicine Week -- Data detailed on Life Science Research have been presented. According to news reporting out of Brussels, Belgium, by NewsRx editors, research stated, "The aim of this work was to automate a sample preparation procedure extracting morphine, hydromorphone, oxymorphone, norcodeine, codeine, dihydrocodeine, oxycodone, 6-monoacetyl-morphine, hydrocodone, ethylmorphine, benzoylecgonine, cocaine, cocaethylene, tramadol, meperidine, pentazocine, fentanyl, norfentanyl, buprenorphine, norbuprenorphine, propoxyphene, methadone and 2-ethylidene-1,5-dimethyl-3,3-diphenylpyrrolidine from urine samples. Samples were extracted by solid-phase extraction (SPE) with cation exchange cartridges using a TECAN Freedom Evo 100 base robotic system, including a hydrolysis step previous extraction when required."

Our news journalists obtained a quote from the research from the National Institute of Criminalistics and Criminology, "Block modules were carefully selected in order to use the same consumable material as in manual procedures to reduce cost and/or manual sample transfers. Moreover, the present configuration included pressure monitoring pipetting increasing pipetting accuracy and detecting sampling errors. The compounds were then separated in a chromatographic run of 9 min using a BEH Phenyl analytical column on a ultra-performance liquid chromatography-tandem mass spectrometry system. Optimization of the SPE was performed with different wash conditions and elution solvents. Intra-and inter-day relative standard deviations (RSDs) were within 15% and bias was within 15% for most of the compounds. Recovery was >69% (RSD

According to the news editors, the research concluded: "Automation resulted in improved precision and accuracy, and a minimum operator intervention, leading to safer sample handling and less time-consuming procedures."

For more information on this research see: Validation of an automated solid-phase extraction method for the analysis of 23 opioids, cocaine, and metabolites in urine with ultra-performance liquid chromatography-tandem mass spectrometry. Journal of Analytical Toxicology, 2014;38(5):280-8. (Oxford University Press - www.oup.com/; Journal of Analytical Toxicology - jat.oxfordjournals.org)

Our news journalists report that additional information may be obtained by contacting M.D.E.L.M. Ramirez Fernandez, Federal Public Service Justice, National Institute of Criminalistics and Criminology, Chaussee de Vilvorde 100, 1120 Brussels, Belgium. Additional authors for this research include F. Van Durme, S.M. Wille, V. di Fazio, N. Kummer and N. Samyn (see also Life Science Research).

Keywords for this news article include: Europe, Belgium, Brussels, Life Science Research.

Our reports deliver fact-based news of research and discoveries from around the world. Copyright 2014, NewsRx LLC


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Source: Health & Medicine Week


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