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Researchers at CEA Saclay Target Peptide Research (Directing peptide crystallization through curvature control of nanotubes)

July 22, 2014



By a News Reporter-Staff News Editor at Life Science Weekly -- Data detailed on Life Science Research have been presented. According to news originating from Gif sur Yvette, France, by NewsRx correspondents, research stated, "In the absence of efficient crystallization methods, the molecular structures of fibrous assemblies have so far remained rather elusive. In this paper, we present a rational method to crystallize the lanreotide octapeptide by modification of a residue involved in a close contact.Indeed, we show that it is possible to modify the curvature of the lanreotide nanotubes and hence their diameter."

Our news journalists obtained a quote from the research from CEA Saclay, "This fine tuning leads to crystallization because the radius of curvature of the initially bidimensional peptide wall can be increased up to a point where the wall is essentially flat and a crystal is allowed to grow along a third dimension. By comparing X-ray diffraction data and Fourier transform Raman spectra, we show that the nanotubes and the crystals share similar cell parameters and molecular conformations, proving that there is indeed a structural continuum between these two morphologies."

According to the news editors, the research concluded: "These results illustrate a novel approach to crystallization and represent the first step towards the acquisition of an angstrom-resolution structure of the lanreotide nanotubes -sheet assembly."

For more information on this research see: Directing peptide crystallization through curvature control of nanotubes. Journal of Peptide Science, 2014;20(7):508-516. Journal of Peptide Science can be contacted at: Wiley-Blackwell, 111 River St, Hoboken 07030-5774, NJ, USA. (Wiley-Blackwell - www.wiley.com/; Journal of Peptide Science - onlinelibrary.wiley.com/journal/10.1002/(ISSN)1099-1387)

The news correspondents report that additional information may be obtained from F. Gobeaux, CEA Saclay, SCBM, iBiTec S, F-91191 Gif Sur Yvette, France. Additional authors for this research include C. Tarabout, N. Fay, C. Meriadec, M. Ligeti, D.A. Buisson, J.C. Cintrat, F. Artzner and M. Paternostre (see also Life Science Research).

Keywords for this news article include: France, Europe, Gif sur Yvette, Life Science Research

Our reports deliver fact-based news of research and discoveries from around the world. Copyright 2014, NewsRx LLC


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Source: Life Science Weekly


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