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Research Conducted at University of Navarra Has Updated Our Knowledge about Nanoparticles (In vitro intestinal co-culture cell model to evaluate...

July 22, 2014



Research Conducted at University of Navarra Has Updated Our Knowledge about Nanoparticles (In vitro intestinal co-culture cell model to evaluate intestinal absorption of edelfosine lipid nanoparticles)

By a News Reporter-Staff News Editor at Cancer Weekly -- Current study results on Nanoparticles have been published. According to news reporting out of Pamplona, Spain, by NewsRx editors, research stated, "Nanotechnology is providing a new therapeutic paradigm by enhancing drug efficacy and preventing side-effects. Edelfosine is a synthetic ether lipid analogue of platelet activating factor with high antitumor activity."

Our news journalists obtained a quote from the research from the University of Navarra, "The encapsulation of this potent antitumor drug in lipid nanoparticles increases its oral bioavailability; moreover, it prevents the hemolytic and gastrointestinal side-effects of the free drug. The literature points towards lymphatic absorption of lipid nanoparticles after oral administration, and previous in vitro and in vivo studies stress the protection against toxicity that these nanosystems provide. The present study is intended to assess the permeability of lipid nanoparticles across the intestinal barrier. Caco-2 monoculture and Caco-2/Raji co-culture were used as in vitro models of enterocytes and Microfold cells respectively. Results showed that free drug is internalized and possibly metabolized in enterocytes."

According to the news editors, the research concluded: "These results do not correlate with those observed in vivo when edelfosine-lipid nanoparticles were administered orally in mice, which suggests that the microfold model is not a good model to study the absorption of edelfosine-lipid nanoparticles across the intestinal barrier in vitro."

For more information on this research see: In vitro intestinal co-culture cell model to evaluate intestinal absorption of edelfosine lipid nanoparticles. Current Topics In Medicinal Chemistry, 2014;14(9):1124-32. (Bentham Science Publishers - www.benthamscience.com; Current Topics In Medicinal Chemistry - www.benthamscience.com/ctmc/index.htm)

Our news journalists report that additional information may be obtained by contacting B. Lasa-Saracibar, Dept. of Pharmaceutics and Pharmaceutical Technology, School of Pharmacy, University of Navarra, C, Irunlarrea 1, E-31080 Pamplona, Spain. Additional authors for this research include M. Guada, V. Sebastian and M.J Blanco-Prieto (see also Nanoparticles).

Keywords for this news article include: Spain, Europe, Pamplona, Nanotechnology, Emerging Technologies.

Our reports deliver fact-based news of research and discoveries from around the world. Copyright 2014, NewsRx LLC


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Source: Cancer Weekly


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