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Reports on Stem Cells from UCL Institute of Child Health Provide New Insights [Human skeletal muscle-derived CD133(+) cells form functional satellite...

July 23, 2014



Reports on Stem Cells from UCL Institute of Child Health Provide New Insights [Human skeletal muscle-derived CD133(+) cells form functional satellite cells after intramuscular transplantation in immunodeficient host mice]

By a News Reporter-Staff News Editor at Biotech Week -- Investigators publish new report on Stem Cell Research. According to news reporting originating from London, United Kingdom, by NewsRx correspondents, research stated, "Stem cell therapy is a promising strategy for treatment of muscular dystrophies. In addition to muscle fiber formation, reconstitution of functional stem cell pool by donor cells is vital for long-term treatment."

Our news editors obtained a quote from the research from the UCL Institute of Child Health, "We show here that some CD133(+) cells within human muscle are located underneath the basal lamina of muscle fibers, in the position of the muscle satellite cell. Cultured hCD133(+) cells are heterogeneous and multipotent, capable of forming myotubes and reserve satellite cells in vitro. They contribute to extensive muscle regeneration and satellite cell formation following intramuscular transplantation into irradiated and cryodamaged tibialis anterior muscles of immunodeficient Rag2-/? chain-/C5-mice. Some donor-derived satellite cells expressed the myogenic regulatory factor MyoD, indicating that they were activated. In addition, when transplanted host muscles were reinjured, there was significantly more newly-regenerated muscle fibers of donor origin in treated than in control, nonreinjured muscles, indicating that hCD133(+) cells had given rise to functional muscle stem cells, which were able to activate in response to injury and contribute to a further round of muscle regeneration."

According to the news editors, the research concluded: "Our findings provide new evidence for the location and characterization of hCD133(+) cells, and highlight that these cells are highly suitable for future clinical application."

For more information on this research see: Human skeletal muscle-derived CD133(+) cells form functional satellite cells after intramuscular transplantation in immunodeficient host mice. Molecular Therapy, 2014;22(5):1008-17. (Elsevier - www.elsevier.com; Molecular Therapy - www.elsevier.com/wps/product/cws_home/622922)

The news editors report that additional information may be obtained by contacting J. Meng, The Dubowitz Neuromuscular Centre, UCL Institute of Child Health, London, UK. Additional authors for this research include S. Chun, R. Asfahani, H. Lochmuller, F. Muntoni and J. Morgan (see also Stem Cell Research).

Keywords for this news article include: London, Europe, United Kingdom, Stem Cell Research.

Our reports deliver fact-based news of research and discoveries from around the world. Copyright 2014, NewsRx LLC


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Source: Biotech Week


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