Reports from Pusan National University Hospital Advance Knowledge in Stem Cells (Magnetic resonance imaging pattern of bone marrow involvement as a new predictive parameter of disease progression in newly diagnosed patients with multiple ...)
By a News Reporter-Staff News Editor at Biotech Week -- Fresh data on Stem Cell Research are presented in a new report. According to news reporting from Pusan, South Korea, by NewsRx journalists, research stated, "We investigated the prognostic value of the magnetic resonance imaging (MRI) pattern of bone marrow involvement in patients with multiple myeloma (MM) eligible for autologous stem cell transplantation (ASCT). 126 patients with untreated MM indicated for ASCT underwent spine MRI and cytogenetic analysis at diagnosis. All patients received ASCT after induction therapy of VAD (vincristine, doxorubicin, dexamethasone; n=55) or a thalidomide-based regimen (TCD; n=71)."
The news correspondents obtained a quote from the research from Pusan National University Hospital, "Thalidomide maintenance therapy was performed in 68 patients. The MRI pattern was normal in 27, focal in 47, and diffuse/variegated in 52 patients. Patients with the diffuse/variegated pattern showed significantly higher stage (P=0038), higher -2 microglobulin level (P=0001) and severe anaemia (P=0015). However, the cytogenetics were not different among the MRI patterns (P=0890). Progression-free survival (PFS) was lower in the diffuse/variegated pattern (P=0002) than other patterns, but not overall survival (OS) (P=0058). Thalidomide maintenance therapy was correlated only with PFS (P= 0001). High-risk cytogenetics were associated with both poorer PFS (P
According to the news reporters, the research concluded: "The diffuse/variegated MRI pattern is a novel prognostic factor for disease progression in MM patients eligible for ASCT."
For more information on this research see: Magnetic resonance imaging pattern of bone marrow involvement as a new predictive parameter of disease progression in newly diagnosed patients with multiple myeloma eligible for autologous stem cell transplantation. British Journal of Haematology, 2014;165(6):777-785. British Journal of Haematology can be contacted at: Wiley-Blackwell, 111 River St, Hoboken 07030-5774, NJ, USA. (Wiley-Blackwell - www.wiley.com/; British Journal of Haematology - onlinelibrary.wiley.com/journal/10.1111/(ISSN)1365-2141)
Our news journalists report that additional information may be obtained by contacting M.K. Song, Pusan Natl Univ Hosp, Dept. of Radiol, Pusan, South Korea. Additional authors for this research include J.S. Chung, J.J. Lee, C.K. Min, J.S. Ahn, S.M. Lee, D.Y. Shin, S.H. Bae, J. Hong, G.W. Lee, I.S. Lee and H.J. Shin (see also Stem Cell Research).
Keywords for this news article include: Asia, Antiinfectives, Antineoplastics, Pharmaceuticals, Pusan, Drugs, Surgery, Therapy, Oncology, South Korea, Bone Marrow, Thalidomide, Leprostatics, Bone Research, Immune System, Multiple Myeloma, Paraproteinemias, Vascular Diseases, Disease Attributes, Magnetic Resonance, Stem Cell Research, Disease Progression
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