Reports from Institute of Chemical Technology Advance Knowledge in Diarylheptanoids (Process intensification approach for preparation of curcumin nanoparticles via solvent-nonsolvent nanoprecipitation using spinning disc reactor)
By a News Reporter-Staff News Editor at Clinical Trials Week -- Current study results on Diarylheptanoids have been published. According to news reporting originating from Maharashtra, India, by NewsRx correspondents, research stated, "Continuous preparation of curcumin nanoparticles via solvent-nonsolvent (S-NS) precipitation by using spinning disc reactor was investigated. The process intensification by spinning disc reactor (SDR) along with the comparative study of conventional mechanical agitated contactor was carried out."
Our news editors obtained a quote from the research from the Institute of Chemical Technology, "Solvent used for curcumin precipitation in this study was ethanol whereas non-solvent deionised water. Influences of various operating parameters for spinning disc process; such as flow rate of S-NS, S-NS ratio, concentration of curcumin, disc characteristics, concentration of protecting agent and rotating disc speed were examined on the nanoparticles size. The average optimum curcumin particles size was obtained in the range 180-220 nm in consideration with particles size distribution at a flow rate of 200 mL min(-1); curcumin concentration of 0.5 g L-1 in ethanol; polyvinylpyrilodine (PVP) concentration of 1 g L-1 in deionised water; S:NS ratio 1:4 and operating disc speed of 1500 rpm. Particles were characterized by using XRD, FT-IR, DSC and SEM which showed decrease in the crystallinity after the nanoprecipitation of curcumin."
According to the news editors, the research concluded: "The dissolution rates of the fabricated curcumin nanoparticle were found drastically higher than original curcumin."
For more information on this research see: Process intensification approach for preparation of curcumin nanoparticles via solvent-nonsolvent nanoprecipitation using spinning disc reactor. Chemical Engineering and Processing, 2014;80():1-10. Chemical Engineering and Processing can be contacted at: Elsevier Science Sa, PO Box 564, 1001 Lausanne, Switzerland. (Elsevier - www.elsevier.com; Chemical Engineering and Processing - www.elsevier.com/wps/product/cws_home/504081)
The news editors report that additional information may be obtained by contacting W.H. Khan, Inst Chem Technol, Dept. of Chem Engn, Mumbai 400019, Maharashtra, India (see also Diarylheptanoids).
Keywords for this news article include: Asia, India, Alkanes, Curcumin, Catechols, Maharashtra, Hydrocarbons, Nanoparticle, Nanotechnology, Diarylheptanoids, Organic Chemicals, Emerging Technologies
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