Recent Studies from Nanjing Medical University Add New Data to Xenografts [Enhanced Antitumor Efficacy by D-Glucosamine-Functionalized and Paclitaxel-Loaded Poly(Ethylene Glycol)-Co-Poly(Trimethylene Carbonate) Polymer Nanoparticles]
By a News Reporter-Staff News Editor at Biotech Week -- Research findings on Biotechnology are discussed in a new report. According to news originating from Jiangsu, People's Republic of China, by NewsRx correspondents, research stated, "The poor selectivity of chemotherapeutics for cancer treatment may lead to dose-limiting side effects that compromise clinical outcomes. To solve the problem, surface-functionalized polymer nanoparticles are regarded as promising tumor-targeting delivery system."
Our news journalists obtained a quote from the research from Nanjing Medical University, "On the basis of glucose transporter (GLUT) overexpression on cancer cells, D-glucosamine-conjugated and paclitaxel-loaded poly(ethylene glycol)-co-poly(trimethylene carbonate) copolymer nanoparticles (DGlu-NP/PTX) were developed as potential tumor-targeting drug delivery system in this study. Because of the high affinity between D-glucosamine and GLUT, DGlu-NP/PTX could target to tumor tissue through GLUT-mediated endocytosis to improve the selectivity of PTX. DGlu-NP/PTX was prepared by emulsion/solvent evaporation technique and characterized in terms of morphology, size, and zeta potential. In vitro evaluation of two-dimensional cells and three-dimensional tumor spheroids revealed that DGlu-NP/PTX was more potent than those of plain nanoparticles (NP/PTX) and Taxol. In vivo multispectral fluorescent imaging indicated that DGlu-NP had higher specificity and efficiency on subcutaneous xenografts tumor of mouse. Furthermore, DGlu-NP/PTX showed the greatest tumor growth inhibitory effect on in vivo subcutaneous xenografts model with no evident toxicity."
According to the news editors, the research concluded: "Therefore, these results demonstrated that DGlu-NP/PTX could be used as potential vehicle for cancer treatment."
For more information on this research see: Enhanced Antitumor Efficacy by D-Glucosamine-Functionalized and Paclitaxel-Loaded Poly(Ethylene Glycol)-Co-Poly(Trimethylene Carbonate) Polymer Nanoparticles. Journal of Pharmaceutical Sciences, 2014;103(5):1487-1496. Journal of Pharmaceutical Sciences can be contacted at: Wiley-Blackwell, 111 River St, Hoboken 07030-5774, NJ, USA. (Wiley-Blackwell - www.wiley.com/; Journal of Pharmaceutical Sciences - onlinelibrary.wiley.com/journal/10.1002/(ISSN)1520-6017)
The news correspondents report that additional information may be obtained from X.Y. Jiang, Nanjing Medical University, Sch Pharm, Dept. of Pharmaceut, Nanjing 211166, Jiangsu, People's Republic of China. Additional authors for this research include H.L. Xin, J.J. Gu, F.Y. Du, C.L. Feng, Y.K. Xie and X.L. Fang (see also Biotechnology).
Keywords for this news article include: Asia, Antineoplastics, Biotechnology, Pharmaceuticals, Drugs, Anions, Cancer, Jiangsu, Alkenes, Taxoids, Therapy, Alkalies, Oncology, Terpenes, Xenograft, Carbonates, Paclitaxel, Hydrocarbons, Nanoparticle, Carbonic Acid, Cycloparaffins, Nanotechnology, Ethylene Glycols, Organic Chemicals, Xenotransplantion
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