New Peptides and Proteins Findings from Soochow University Described (N-Succinyl-chitosan nanoparticles coupled with low-density lipoprotein for targeted osthole-loaded delivery to low-density lipoprotein receptor-rich tumors)
By a News Reporter-Staff News Editor at Life Science Weekly -- Researchers detail new data in Proteins. According to news reporting originating from Jiangsu, People's Republic of China, by NewsRx correspondents, research stated, "N-Succinyl-chitosan (NSC) was synthesized and NSC nanoparticles (NPs) with loaded osthole (Ost) (Ost/NSC-NPs) were prepared by emulsion solvent diffusion. Subsequently, low-density lipoprotein (LDL)-mediated NSC-NPs with loaded Ost (Ost/LDL-NSC-NPs) were obtained by coupling LDL with Ost/NSC-NPs through amide linkage."
Our news editors obtained a quote from the research from Soochow University, "The average particle size of Ost/NSC-NPs was approximately 145 nm, the entrapment efficiency was 78.28%+/-2.06%, and the drug-loading amount was 18.09%+/-0.17%. The release of Ost from Ost/NSC-NPs in vitro showed a more evident sustained effect than the native material. The half maximal inhibitory concentration of Ost/LDL-NSC-NPs was only 16.23% that of the free Ost at 24 hours in HepG2 cells. Ost inhibited HepG2 cell proliferation by arresting cells in the synthesis phase of the cell cycle and by triggering apoptosis. Cellular uptake and subcellular localization in vitro and near-infrared fluorescence real-time imaging in vivo showed that Ost/LDL-NSC-NPs had high targeting efficacy."
According to the news editors, the research concluded: "Therefore, LDL-NSC-NPs are a promising system for targeted Ost delivery to liver tumor."
For more information on this research see: N-Succinyl-chitosan nanoparticles coupled with low-density lipoprotein for targeted osthole-loaded delivery to low-density lipoprotein receptor-rich tumors. International Journal of Nanomedicine, 2014;9():2919-2932. International Journal of Nanomedicine can be contacted at: Dove Medical Press Ltd, PO Box 300-008, Albany, Auckland 0752, New Zealand (see also Proteins).
The news editors report that additional information may be obtained by contacting C.G. Zhang, Soochow Univ, Affiliated Hosp 2, Invas Technol Department, Suzhou 215123, Jiangsu, People's Republic of China. Additional authors for this research include Q.L. Zhu, Y. Zhou, Y. Liu, W.L. Chen, Z.Q. Yuan, S.D. Yang, X.F. Zhou, A.J. Zhu, X.N. Zhang and Y. Jin.
Keywords for this news article include: Asia, Lipids, Jiangsu, Nanoparticle, Nanotechnology, Emerging Technologies, Lipoprotein Receptors, Cell Surface Receptors, People's Republic of China
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