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New Medicinal Chemistry Study Findings Have Been Reported from Department of Chemical Engineering (Recent advances in delivery through the...

July 25, 2014



New Medicinal Chemistry Study Findings Have Been Reported from Department of Chemical Engineering (Recent advances in delivery through the blood-brain barrier)

By a News Reporter-Staff News Editor at Health & Medicine Week -- Investigators publish new report on Health and Medicine. According to news originating from Auburn, Alabama, by NewsRx correspondents, research stated, "Current routes of delivering therapeutics to the brain to treat a variety of neurologic conditions include intracerebral, intrathecal, and intranasal delivery. Though successes have been achieved through the use of these methods, each has limitations that warrant a more universal delivery system involving the intravenous pathway."

Our news journalists obtained a quote from the research from the Department of Chemical Engineering, "Two main barriers to intravenous delivery are the blood-brain barrier (BBB) and the blood-cerebrospinal fluid barrier. This review discusses potential methods for overcoming barriers of intravenous-mediated brain targeting as well as highlights aspects of the highly restrictive BBB anatomy that are important to consider in the design of successful drug delivery systems. Recent advances in intravenous delivery to the brain have exploited receptor-mediated transcytosis and BBB disruption, as well as control of carrier properties. Currently, three predominant synthetic carriers are being studied to transport therapeutics across the BBB: liposomes, metallic nanoparticles, and polymersomes."

According to the news editors, the research concluded: "This article also focuses on receptors that may be upregulated by brain endothelial cells and their ability to significantly increase brain tissue drug distribution when specific targeting moieties to these receptors are attached to synthetic nanocarriers."

For more information on this research see: Recent advances in delivery through the blood-brain barrier. Current Topics In Medicinal Chemistry, 2014;14(9):1148-60. (Bentham Science Publishers - www.benthamscience.com; Current Topics In Medicinal Chemistry - www.benthamscience.com/ctmc/index.htm)

The news correspondents report that additional information may be obtained from J.M. Larsen, Biomimetic & Biohybrid Materials, Biomedical Devices and Drug Delivery Laboratories, Dept. of Chemical Engineering, Samuel Ginn College of Engineering, Auburn, AL 36849, United States. Additional authors for this research include D.R. Martin and M.E Byrne (see also Health and Medicine).

Keywords for this news article include: Auburn, Alabama, United States, Health and Medicine, North and Central America.

Our reports deliver fact-based news of research and discoveries from around the world. Copyright 2014, NewsRx LLC


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Source: Health & Medicine Week


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