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New Findings on Doxorubicin Therapy from University of Ege Summarized (In vitro Evaluation of Doxorubicin-Incorporated Magnetic Albumin Nanospheres)

July 23, 2014



By a News Reporter-Staff News Editor at Biotech Week -- Current study results on Drugs and Therapies have been published. According to news reporting originating from Izmir, Turkey, by NewsRx correspondents, research stated, "Magnetic albumin nanospheres that incorporate doxorubicin (M-DOX-BSA-NPs) were prepared previously by our research group to develop magnetically responsive drug carrier system. This nanocarrier was synthesized as a drug delivery system for targeted chemotherapy."

Our news editors obtained a quote from the research from the University of Ege, "In this work, cytotoxic effects of doxorubicin (DOX)-loaded/unloaded or magnetic/non-magnetic nanoparticles and free DOX against PC-3 cells and A549 cells were determined with the MTT test and the results were compared with each other. DOX-loaded magnetic albumin nanospheres (M-DOX-BSA-NPs) were found more cytotoxic than other formulations. The quantitative data obtained from flow cytometry analysis further verified the higher targeting and killing ability of M-DOX-BSA-NPs than free DOX on both of the cancer cell lines. Additionally, the results of cell cycle analysis have showed that M-DOX-BSA-NPs affected G1 and G2 phases. Finally, cell images were obtained using spin-disk confocal microscopy, and cellular uptake of M-DOX-BSA-NPs was visualized."

According to the news editors, the research concluded: "The findings of this study suggest that M-DOX-BSA-NPs represent a potential doxorubicin delivery system for targeted drug transport into prostate and lung cancer cells."

For more information on this research see: In vitro Evaluation of Doxorubicin-Incorporated Magnetic Albumin Nanospheres. Chemical Biology & Drug Design, 2014;84(1):108-115. Chemical Biology & Drug Design can be contacted at: Wiley-Blackwell, 111 River St, Hoboken 07030-5774, NJ, USA. (Wiley-Blackwell - www.wiley.com/; Chemical Biology & Drug Design - onlinelibrary.wiley.com/journal/10.1111/(ISSN)1747-0285)

The news editors report that additional information may be obtained by contacting A. Zeybek, Ege University, Fac Sci, Dept. of Biochem, TR-35100 Izmir, Turkey. Additional authors for this research include G. Sanli-Mohamed, G. Ak, H. Yilmaz and S.H. Sanlier (see also Drugs and Therapies).

Keywords for this news article include: Antibiotics - Antineoplastics, Pharmaceuticals, Izmir, Turkey, Eurasia, Drugs and Therapies, Doxorubicin Hydrochloride

Our reports deliver fact-based news of research and discoveries from around the world. Copyright 2014, NewsRx LLC


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Source: Biotech Week


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