New Findings in Stem Cells Described from Xuanwu Hospital (Neurorestorative effect of urinary bladder matrix-mediated neural stem cell transplantation following traumatic brain injury in rats)
By a News Reporter-Staff News Editor at Biotech Week -- Investigators publish new report on Stem Cell Research. According to news reporting originating in Beijing, People's Republic of China, by NewsRx journalists, research stated, "Traumatic brain injury (TBI) is a leading cause of cell death and disability among young adults and lacks a successful therapeutic strategy. The multiphasic injuries of TBI severely limit the success of conventional pharmacological approaches."
The news reporters obtained a quote from the research from Xuanwu Hospital, "Recent successes with transplantation of stem cells in bioactive scaffolds in other injury paradigms provide new hope for the treatment of TBI. In this study, we transplanted neural stem cells (0.5x10(5) cells/l) cultured in a bioactive scaffold derived from porcine urinary bladder matrix (UBM; 4 injection sites, 2.5l each) into the rat brain following controlled cortical impact (CCI, velocity, 4.0 m/sec; duration, 0.5 sec; depth, 3.2mm). We evaluated the effectiveness of this strategy to combat the loss of motor, memory and cognitive faculties. Before transplantation, compatibility experiments showed that UBM was able to support extended proliferation and differentiation of neural stem cells. Together with its reported anti-inflammatory properties and rapid degradation characteristics in vivo, UBM emerged to be an ideal scaffold. The transplants reduced neuron/tissue loss and white matter injury, and also significantly ameliorated motor, memory, and cognitive impairments. Furthermore, exposure to UBM alone was sufficient to decrease the loss of sensorimotor skills from TBI (examined 3-28 days post-CCI). However, only UBMs that contained proliferating neural stem cells helped attenuate memory and cognitive impairments (examined 26-28 days post-CCI)."
According to the news reporters, the research concluded: "In summary, these results demonstrate the therapeutic efficacy of stem cells in bioactive scaffolds against TBI and show promise for translation into future clinical use."
For more information on this research see: Neurorestorative effect of urinary bladder matrix-mediated neural stem cell transplantation following traumatic brain injury in rats. Cns & Neurological Disorders Drug Targets, 2013;12(3):413-25 (see also Stem Cell Research).
Our news correspondents report that additional information may be obtained by contacting J.Y. Wang, Dept. of Neurosurgery, Xuanwu Hospital of Capital Medical University, 45 Changchun St, Beijing, People's Republic of China. Additional authors for this research include A.K. Liou, Z.H. Ren, L. Zhang, B.N. Brown, X.T. Cui, S.F. Badylak, Y.N. Cai, Y.Q. Guan, R.K. Leak, J. Chen, X. Ji and L. Chen.
Keywords for this news article include: Asia, Tissue Engineering, Biomedical Engineering, Biomedicine, Beijing, Surgery, Bioengineering, Brain Injuries, Stem Cell Research, Cell Transplantation, Craniocerebral Trauma, Traumatic Brain Injury, People's Republic of China.
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