New Findings in Peptide Research Described from Shimadzu Corporation [Suppressive immune response of poly-(sarcosine) chains in peptide-nanosheets in contrast to polymeric micelles]
By a News Reporter-Staff News Editor at Biotech Week -- A new study on Life Science Research is now available. According to news reporting originating in Kyoto, Japan, by NewsRx journalists, research stated, "Nanoparticles are expected to be applicable for the theranostics as a carrier of the diagnostic and therapeutic agents. Lactosome is a polymeric micelle composed of amphiphilic polydepsipeptide, poly(sarcosine)64-block-poly(l-lactic acid)30, which was found to accumulate in solid tumors through the enhanced permeability and retention effect."
The news reporters obtained a quote from the research from Shimadzu Corporation, "However, lactosome was captured by liver on the second administration to a mouse. This phenomenon is called as the accelerated blood clearance phenomenon. On the other hand, peptide-nanosheet composed of amphiphilic polypeptide, poly(sarcosine)60-block-(l-Leu-Aib)6, where the poly(l-lactic acid) block in lactosome was replaced with the (l-Leu-Aib)6 block, abolished the accelerated blood clearance phenomenon. The ELISA and in vivo near-infrared fluorescence imaging revealed that peptide-nanosheets did not activate the immune system despite the same hydrophilic block being used."
According to the news reporters, the research concluded: "The high surface density of poly(sarcosine) chains on the peptide-nanosheet may be one of the causes of the suppressive immune response."
For more information on this research see: Suppressive immune response of poly-(sarcosine) chains in peptide-nanosheets in contrast to polymeric micelles. Journal of Peptide Science, 2014;20(7):570-577. Journal of Peptide Science can be contacted at: Wiley-Blackwell, 111 River St, Hoboken 07030-5774, NJ, USA. (Wiley-Blackwell - www.wiley.com/; Journal of Peptide Science - onlinelibrary.wiley.com/journal/10.1002/(ISSN)1099-1387)
Our news correspondents report that additional information may be obtained by contacting E. Hara, Shimadzu Co Ltd, Technol Res Lab, Seika, Kyoto 6190237, Japan. Additional authors for this research include M. Ueda, C.J. Kim, A. Makino, I. Hara, E. Ozeki and S. Kimura (see also Life Science Research).
Keywords for this news article include: Asia, Kyoto, Japan, Life Science Research
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