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New Findings from University of Sherbrooke Describe Advances in DNA Research (A Single Subexcitation-Energy Electron Can Induce a Double-Strand Break...

July 25, 2014



New Findings from University of Sherbrooke Describe Advances in DNA Research (A Single Subexcitation-Energy Electron Can Induce a Double-Strand Break in DNA Modified by Platinum Chemotherapeutic Drugs)

By a News Reporter-Staff News Editor at Energy Weekly News -- New research on DNA Research is the subject of a report. According to news reporting originating from Sherbrooke, Canada, by VerticalNews correspondents, research stated, "The sensitization of malignant cells to ionizing radiation is the clinical rationale for the use of platinum-drug-based concurrent chemoradiotherapy (CCRT) for cancer treatment; however, the specific mechanisms of radiosensitization and their respective contributions still remain unknown. Biological mechanisms such as inhibition of DNA repair may contribute to the efficacy of CCRT; nevertheless, there is a dearth of information on the possible contribution of nanoscopic mechanisms to the generation of lethal DNA lesions, such as double-strand breaks (DSB)."

Our news editors obtained a quote from the research from the University of Sherbrooke, "The present study demonstrates that the abundant near zero-eV (0.5eV) electrons, created by ionizing radiation during radiotherapy, induce DSB in supercoiled plasmid DNA modified by platinum-containing anticancer drugs (Ptdrugs), but not in unmodified DNA. They do so more efficiently than other types of radiation, including soft X-rays and 10eV electrons. The formation of DSB by 0.5eV electrons is found to be a single-hit process."

According to the news editors, the research concluded: "These findings reveal insights into the radiosensitization mechanism of Ptdrugs that can have implications for the development of optimal clinical protocols for platinum-based CCRT and the deployment of insitu sources of subexcitation-energy electrons (e.g., Auger electron-emitting radionuclides) to efficiently enhance DSB formation in DNA modified by Ptdrugs in malignant cells."

For more information on this research see: A Single Subexcitation-Energy Electron Can Induce a Double-Strand Break in DNA Modified by Platinum Chemotherapeutic Drugs. Chemmedchem, 2014;9(6):1145-1149. Chemmedchem can be contacted at: Wiley-V C H Verlag Gmbh, Boschstrasse 12, D-69469 Weinheim, Germany. (Wiley-Blackwell - www.wiley.com/; Chemmedchem - onlinelibrary.wiley.com/journal/10.1002/(ISSN)1860-7187)

The news editors report that additional information may be obtained by contacting M. Rezaee, University of Sherbrooke, Fac Med & Hlth Sci, Dept. of Nucl Med & Radiobiol, Sherbrooke, PQ J1H 5N4, Canada. Additional authors for this research include E. Alizadeh, P. Cloutier, D.J. Hunting and L. Sanche.

Keywords for this news article include: Quebec, Canada, Sherbrooke, DNA Research, North and Central America

Our reports deliver fact-based news of research and discoveries from around the world. Copyright 2014, NewsRx LLC


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Source: Energy Weekly News


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