New Findings from Tel Aviv University in the Area of Nanoparticles Reported (Alginate-coated magnetic nanoparticles for noninvasive MRI of extracellular calcium)
By a News Reporter-Staff News Editor at Biotech Week -- Investigators publish new report on Nanoparticles. According to news originating from Tel Aviv, Israel, by NewsRx correspondents, research stated, "Nanoparticles (NPs) have great potential to increase the diagnostic capacity of many imaging modalities. MRI is currently regarded as the method of choice for the imaging of deep tissues, and metal ions, such as calcium ions (Ca2+), are essential ingredients for life."
Our news journalists obtained a quote from the research from Tel Aviv University, "Despite the tremendous importance of Ca2+ for the well-being of living systems, the noninvasive determination of the changes in Ca2+ levels in general, and extracellular Ca2+ levels in particular, in deep tissues remains a challenge. Here, we describe the preparation and contrast mechanism of a flexible easy to prepare and selective superparamagnetic iron oxide (SPIO) NPs for the noninvasive determination of changes in extracellular Ca2+ levels using conventional MRI. We show that SPIO NPs coated with monodisperse and purified alginate, having a specific molecular weight, provide a tool to selectively determine Ca2+ concentrations in the range of 250 mu M to 2.5mM, even in the presence of competitive ions. The alginate-coated magnetic NPs (MNPs) aggregate in the presence of Ca2+, which, in turn, affects the T-2 relaxation of the water protons in their vicinity. The new alginatecoated SPIO NP formulations, which have no effect on cell viability for 24 h, allow the detection of Ca2+ levels secreted from ischemic cell cultures and the qualitative examination of the change in extracellular Ca2+ levels in vivo."
According to the news editors, the research concluded: "These results demonstrate that alginate-coated MNPs can be used, at least qualitatively, as a platform for the noninvasive MRI determination of extracellular Ca2+ levels in myriad in vitro and in vivo biomedical applications."
For more information on this research see: Alginate-coated magnetic nanoparticles for noninvasive MRI of extracellular calcium. NMR in Biomedicine, 2014;27(7):774-783. NMR in Biomedicine can be contacted at: Wiley-Blackwell, 111 River St, Hoboken 07030-5774, NJ, USA. (Wiley-Blackwell - www.wiley.com/; NMR in Biomedicine - onlinelibrary.wiley.com/journal/10.1002/(ISSN)1099-1492)
The news correspondents report that additional information may be obtained from A. Bar-Shir, Tel Aviv University, Neurosci Lab, Felsenstein Med Res Center, Dept. of NeurolRabin Med CenterSackler Fac Med, IL-69978 Tel Aviv, Israel. Additional authors for this research include L. Avram, S. Yariv-Shoushan, D. Anaby, S. Cohen, N. Segev-Amzaleg, D. Frenkel, O. Sadan, D. Offen and Y. Cohen (see also Nanoparticles).
Keywords for this news article include: Asia, Israel, Tel Aviv, Nanotechnology, Emerging Technologies
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