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New Findings from R. Xu and Colleagues Has Provided New Data on Stem Cells (Screening of bioactive peptides using an embryonic stem cell-based...

July 23, 2014



New Findings from R. Xu and Colleagues Has Provided New Data on Stem Cells (Screening of bioactive peptides using an embryonic stem cell-based neurodifferentiation assay)

By a News Reporter-Staff News Editor at Biotech Week -- Researchers detail new data in Stem Cell Research. According to news reporting originating in Copenhagen, Denmark, by NewsRx journalists, research stated, "Differentiation of pluripotent stem cells, PSCs, towards neural lineages has attracted significant attention, given the potential use of such cells for in vitro studies and for regenerative medicine. The present experiments were designed to identify bioactive peptides which direct PSC differentiation towards neural cells."

The news reporters obtained a quote from the research, "Fifteen peptides were designed based on NCAM, FGFR, and growth factors sequences. The effect of peptides was screened using a mouse embryonic stem cell line expressing luciferase dual reporter construct driven by promoters for neural tubulin and for elongation factor 1. Cell number was estimated by measuring total cellular DNA. We identified five peptides which enhanced activities of both promoters without relevant changes in cell number. We selected the two most potent peptides for further analysis: the NCAM-derived mimetic FGLL and the synthetic NCAM ligand, Plannexin. Both compounds induced phenotypic neuronal differentiation, as evidenced by increased neurite outgrowth. In summary, we used a simple, but sensitive screening approach to identify the neurogenic peptides."

According to the news reporters, the research concluded: "These peptides will not only provide new clues concerning pathways of neurogenesis, but they may also be interesting biotechnology tools for in vitro generation of neurons."

For more information on this research see: Screening of bioactive peptides using an embryonic stem cell-based neurodifferentiation assay. The Aaps Journal [electronic Resource], 2014;16(3):400-12. The Aaps Journal [electronic Resource] can be contacted at: Springer, 233 Spring Street, New York, NY 10013, USA (see also Stem Cell Research).

Our news correspondents report that additional information may be obtained by contacting R. Xu, ENKAM Pharmaceuticals A, S, Copenhagen, Denmark. Additional authors for this research include M. Feyeux, S. Julien, C. Nemes, M. Albrechtsen, A. Dinnyes and K.H Krause.

The publisher of the The Aaps Journal [electronic Resource] can be contacted at: Springer, 233 Spring Street, New York, NY 10013, USA.

Keywords for this news article include: Europe, Denmark, Peptides, Proteins, Copenhagen, Proteomics, Amino Acids, Stem Cell Research.

Our reports deliver fact-based news of research and discoveries from around the world. Copyright 2014, NewsRx LLC


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Source: Biotech Week


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