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New Findings from Japan Science and Technology Agency in the Area of Capillary Electrophoresis Reported (A snapshot of plasma metabolites in...

July 22, 2014



New Findings from Japan Science and Technology Agency in the Area of Capillary Electrophoresis Reported (A snapshot of plasma metabolites in first-episode schizophrenia: a capillary electrophoresis time-of-flight mass spectrometry study)

By a News Reporter-Staff News Editor at Life Science Weekly -- Investigators discuss new findings in Capillary Electrophoresis. According to news reporting from Tokyo, Japan, by NewsRx journalists, research stated, "Few biomarkers have been known that can easily measure clinical conditions in mental illnesses such as schizophrenia. Capillary electrophoresis time-of-flight mass spectrometry (CE-TOFMS) is a new method that can measure ionized and low-molecular-weight metabolites."

The news correspondents obtained a quote from the research from Japan Science and Technology Agency, "To explore global metabolomic alterations that characterize the onset of schizophrenia and identify biomarkers, we profiled the relative and absolute concentrations of the plasma metabolites from 30 patients with first-episode schizophrenia (FESZ, four drug-naive samples), 38 healthy controls and 15 individuals with autism spectrum disorders using CE-TOFMS. Five metabolites had robust changes (increased creatine and decreased betaine, nonanoic acid, benzoic acid and perillic acid) in two independent sample sets. Altered levels of these metabolites are consistent with well-known hypotheses regarding abnormalities of the homocysteine metabolism, creatine kinase-emia and oxidative stress."

According to the news reporters, the research concluded: "Although it should be considered that most patients with FESZ received medication, these metabolites are candidate biomarkers to improve the determination of diagnosis, severity and clinical stages, especially for FESZ."

For more information on this research see: A snapshot of plasma metabolites in first-episode schizophrenia: a capillary electrophoresis time-of-flight mass spectrometry study. Translational Psychiatry, 2014;4():26-33. Translational Psychiatry can be contacted at: Nature Publishing Group, 75 Varick St, 9TH Flr, New York, NY 10013-1917, USA. (Nature Publishing Group - www.nature.com/; Translational Psychiatry - www.nature.com/tp/)

Our news journalists report that additional information may be obtained by contacting S. Koike, Japan Sci & Technol Agcy, NBDC, Tokyo, Japan. Additional authors for this research include M. Bundo, K. Iwamoto, M. Suga, H. Kuwabara, Y. Ohashi, K. Shinoda, Y. Takano, N. Iwashiro, Y. Satomura, T. Nagai, T. Natsubori, M. Tada, H. Yamasue and K. Kasai (see also Capillary Electrophoresis).

Keywords for this news article include: Asia, Tokyo, Japan, Capillary Electrophoresis

Our reports deliver fact-based news of research and discoveries from around the world. Copyright 2014, NewsRx LLC


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Source: Life Science Weekly


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