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New Data from CSIR Illuminate Findings in Myeloid Cells (Toll-like receptor 6 mediated inflammatory and functional responses of zinc oxide...

July 25, 2014



New Data from CSIR Illuminate Findings in Myeloid Cells (Toll-like receptor 6 mediated inflammatory and functional responses of zinc oxide nanoparticles primed macrophages)

By a News Reporter-Staff News Editor at Health & Medicine Week -- Research findings on Myeloid Cells are discussed in a new report. According to news reporting originating in Uttar Pradesh, India, by NewsRx journalists, research stated, "Macrophages are among the most sensitive immune cells because of their phagocytic activity and are prone to become dysfunctional or not able to perform properly if nanoparticle load increases. We have previously reported that zinc oxide nanoparticles (ZNPs) induce inflammatory responses in macrophages that contribute to their death."

The news reporters obtained a quote from the research from CSIR, "Recognition of ZNPs by pattern recognition receptors such as toll-like receptors (TLRs) might be a factor in the initiation of these responses in macrophages. Therefore, in this study we explored the role played by TLR6 and mitogen-activated protein kinase (MAPKs) pathways in the inflammatory responses of macrophages during ZNPs exposure. ZNPs-activated macrophages showed enhanced expression of activation and maturation markers (CD1d, MHC-II, CD86 and CD71). Among various TLRs screened, TLR6 emerged as the most potent activator for ZNPs-induced inflammatory responses. Downstream signalling proteins myeloid differentiation 88, interleukin-1 receptor associated kinase and tumour necrosis factor receptor-associated factor were also enhanced. On inhibiting MAPKs pathways individually, the inflammatory responses such as interleukin-1, interleukin-6, tumour necrosis factor-, cyclooxygenase-2 and inducible nitric oxide synthase were suppressed. TLR6 silencing significantly inhibited the pro-inflammatory cytokine levels, reactive nitrogen species generation and inducible nitric oxide synthase expression. Also, inhibition of MAPKs in the absence of TLR6 signalling validated the link between TLR6 and MAPKs in ZNPs-induced inflammatory responses. TLR6 was found to be co-localized with autophagosomes. Macrophages lacking TLR6 inhibited the autophagosome marker protein-microtubule-associated protein1 light chain 3-isoform II formation and phagocytosis."

According to the news reporters, the research concluded: "These results demonstrate that inflammatory responses caused by ZNPs-activated macrophages strongly depend on TLR6-mediated MAPK signalling."

For more information on this research see: Toll-like receptor 6 mediated inflammatory and functional responses of zinc oxide nanoparticles primed macrophages. Immunology, 2014;142(3):453-464. Immunology can be contacted at: Wiley-Blackwell, 111 River St, Hoboken 07030-5774, NJ, USA. (Wiley-Blackwell - www.wiley.com/; Immunology - onlinelibrary.wiley.com/journal/10.1111/(ISSN)1365-2567)

Our news correspondents report that additional information may be obtained by contacting R. Roy, CSIR Cent Drug Res Inst, Div Parasitol, Lucknow, Uttar Pradesh, India. Additional authors for this research include S.K. Singh, M. Das, A. Tripathi and P.D. Dwivedi (see also Myeloid Cells).

Keywords for this news article include: Asia, India, Kinase, Synthase, Chemicals, Chemistry, Cytokines, Immunology, Zinc Oxide, Macrophages, Interleukins, Nanoparticle, Nitric Oxide, Uttar Pradesh, Myeloid Cells, Nanotechnology, Zinc Compounds, Membrane Proteins, Toll-Like Receptor 6, Emerging Technologies, Enzymes and Coenzymes, Connective Tissue Cells

Our reports deliver fact-based news of research and discoveries from around the world. Copyright 2014, NewsRx LLC


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Source: Health & Medicine Week


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