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New Data from Brookhaven National Laboratory Illuminate Findings in DNA Research (Two-Dimensional DNA-Programmable Assembly of Nanoparticles at...

July 22, 2014

New Data from Brookhaven National Laboratory Illuminate Findings in DNA Research (Two-Dimensional DNA-Programmable Assembly of Nanoparticles at Liquid Interfaces)

By a News Reporter-Staff News Editor at Life Science Weekly -- Researchers detail new data in DNA Research. According to news reporting originating from Upton, New York, by NewsRx correspondents, research stated, "DNA-driven assembly of nanoscale objects has emerged as a powerful platform for the creation of materials by design via self-assembly. Recent years have seen much progress in the experimental realization of this approach for three-dimensional systems."

Our news editors obtained a quote from the research from Brookhaven National Laboratory, "In contrast, two-dimensional (2D) programmable nanoparticle (NP) systems are not well explored, in part due to the difficulties in creating such systems. Here we demonstrate the use of charged liquid interfaces for the assembly and reorganization of 2D systems of DNA-coated NPs. The absorption of DNA-coated NPs to the surface is controlled by the interaction between a positively charged lipid layer and the negatively charged DNA shells of particles. At the same time, interparticle interactions are switchable, from electrostatic repulsion between DNA shells to attraction driven by DNA complementarity, by increasing ionic strength. Using in situ surface X-ray scattering methods and ex situ electron microscopy, we reveal the corresponding structural transformation of the NP monolayer, from a hexagonally ordered 2D lattice to string-like clusters and finally to a weakly ordered network of DNA cross-linked particles. Moreover, we demonstrate that the ability to regulate 2D morphology yields control of the interfacial rheological properties of the NP membrane: from viscous to elastic."

According to the news editors, the research concluded: "Theoretical modeling suggests that the structural adaptivity of interparticle DNA linkages plays a crucial role in the observed 2D transformation of DNA-NP systems at liquid interfaces."

For more information on this research see: Two-Dimensional DNA-Programmable Assembly of Nanoparticles at Liquid Interfaces. Journal of the American Chemical Society, 2014;136(23):8323-8332. Journal of the American Chemical Society can be contacted at: Amer Chemical Soc, 1155 16TH St, NW, Washington, DC 20036, USA. (American Chemical Society -; Journal of the American Chemical Society -

The news editors report that additional information may be obtained by contacting S. Srivastava, Brookhaven Natl Lab, Condensed Matter Phys & Mat Sci Department, Upton, NY 11973, United States. Additional authors for this research include D. Nykypanchuk, M. Fukuto, J.D. Halverson, A.V. Tkachenko, K.G. Yager and O. Gang (see also DNA Research).

Keywords for this news article include: Upton, New York, DNA Research, Nanoparticle, United States, Nanotechnology, Emerging Technologies, North and Central America

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Source: Life Science Weekly

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