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New Cancer Therapy Study Findings Have Been Reported by Researchers at University of Santiago (PEGylated lipid nanocapsules with improved drug...

July 23, 2014



New Cancer Therapy Study Findings Have Been Reported by Researchers at University of Santiago (PEGylated lipid nanocapsules with improved drug encapsulation and controlled release properties)

By a News Reporter-Staff News Editor at Biotech Week -- A new study on Oncology is now available. According to news originating from Santiago de Compostela, Spain, by NewsRx correspondents, research stated, "Drugs with poor lipid and water solubility are some of the most challenging to formulate in nanocarriers, typically resulting in low encapsulation efficiencies and uncontrolled release profiles. PEGylated nanocapsules (PEG-NC) are known for their amenability to diverse modifications that allow the formation of domains with different physicochemical properties, an interesting feature to address a drug encapsulation problem."

Our news journalists obtained a quote from the research from the University of Santiago, "We explored this problem by encapsulating in PEG-NC the promising anticancer drug candidate F10320GD1, used herein as a model for compounds with such characteristics. The nanocarriers were prepared from Miglyol(), lecithin and PEG-sterate through a solvent displacement technique. The resulting system was a homogeneous suspension of particles with size around 200 nm. F10320GD1 encapsulation was found to be very poor (

According to the news editors, the research concluded: "Altogether, the data confirms that PEG-NC show adequate delivery properties for F10320GD1, and underlines its possible utility as an anticancer therapy."

For more information on this research see: PEGylated lipid nanocapsules with improved drug encapsulation and controlled release properties. Current Topics In Medicinal Chemistry, 2014;14(9):1115-23. (Bentham Science Publishers - www.benthamscience.com; Current Topics In Medicinal Chemistry - www.benthamscience.com/ctmc/index.htm)

The news correspondents report that additional information may be obtained from P. Hervella, Ed CIMUS T6D1, Av Barcelona s, n, Campus Vida, Universidad de Santiago de Compostela, 15782 Santiago de Compostela, Spain. Additional authors for this research include M. Alonso-Sande, F. Ledo, M.L. Lucero, M.J. Alonso and M. Garcia-Fuentes (see also Oncology).

Keywords for this news article include: Spain, Europe, Therapy, Oncology, Nanocarriers, Nanotechnology, Controlled Release, Emerging Technologies, Santiago de Compostela.

Our reports deliver fact-based news of research and discoveries from around the world. Copyright 2014, NewsRx LLC


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Source: Biotech Week


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