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New Biotechnology Study Findings Have Been Reported by S. Rameez and Colleagues (High-throughput miniaturized bioreactors for cell culture process...

July 23, 2014



New Biotechnology Study Findings Have Been Reported by S. Rameez and Colleagues (High-throughput miniaturized bioreactors for cell culture process development: Reproducibility, scalability, and control)

By a News Reporter-Staff News Editor at Biotech Week -- Current study results on Technology have been published. According to news reporting from Research Triangle Park, North Carolina, by NewsRx journalists, research stated, "Decreasing the timeframe for cell culture process development has been a key goal toward accelerating biopharmaceutical development. Advanced Microscale Bioreactors (ambr) is an automated micro-bioreactor system with miniature single-use bioreactors with a 10-15 mL working volume controlled by an automated workstation."

The news correspondents obtained a quote from the research, "This system was compared to conventional bioreactor systems in terms of its performance for the production of a monoclonal antibody in a recombinant Chinese Hamster Ovary cell line. The miniaturized bioreactor system was found to produce cell culture profiles that matched across scales to 3 L, 15 L, and 200 L stirred tank bioreactors. The processes used in this article involve complex feed formulations, perturbations, and strict process control within the design space, which are in-line with processes used for commercial scale manufacturing of biopharmaceuticals. Changes to important process parameters in ambr resulted in predictable cell growth, viability and titer changes, which were in good agreement to data from the conventional larger scale bioreactors. ambr was found to successfully reproduce variations in temperature, dissolved oxygen (DO), and pH conditions similar to the larger bioreactor systems. Additionally, the miniature bioreactors were found to react well to perturbations in pH and DO through adjustments to the Proportional and Integral control loop."

According to the news reporters, the research concluded: "The data presented here demonstrates the utility of the ambr system as a high throughput system for cell culture process development."

For more information on this research see: High-throughput miniaturized bioreactors for cell culture process development: Reproducibility, scalability, and control. Biotechnology Progress, 2014;30(3):718-727. Biotechnology Progress can be contacted at: Wiley-Blackwell, 111 River St, Hoboken 07030-5774, NJ, USA. (American Chemical Society - www.acs.org; Biotechnology Progress - www.pubs.acs.org/journal/bipret)

Our news journalists report that additional information may be obtained by contacting S. Rameez, KBI Biopharma Inc, Proc Dev & Mfg, Res Triangle Pk, NC 27709, United States. Additional authors for this research include S.S. Mostafa, C. Miller and A.A. Shukla (see also Technology).

Keywords for this news article include: Technology, United States, North Carolina, Research Triangle Park, North and Central America

Our reports deliver fact-based news of research and discoveries from around the world. Copyright 2014, NewsRx LLC


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Source: Biotech Week


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