Investigators from University of Tehran Target Amoxicillin Therapy (Amoxicillin separation from pharmaceutical solution by pH sensitive nanofiltration membranes)
By a News Reporter-Staff News Editor at Biotech Week -- Investigators discuss new findings in Antibiotics. According to news reporting out of Tehran, Iran, by NewsRx editors, research stated, "In this study, pH-sensitive polysulfone (PSf)/polyactylic acid (PAA) nanofiltration membranes were synthesized for separation of amoxicillin from pharmaceutical wastewater. Moreover, amoxicillin separation was enhanced by pH of filtration environment."
Our news journalists obtained a quote from the research from the University of Tehran, "In order to do so, a flat sheet ultrafiltration (UF) membrane with different pore sizes was prepared by the phase inversion process. A further layer of polyacrylic acid which is sensitive to filtration media pH was grafted onto this fabricated PSf UF membrane surface by UV-initiated graft. Efficiency of amoxicillin separation improved as a result of pH-sensitive nature of amoxicillin as well as surface activity and pH-sensitivity of developed nanofiltration membranes. The results confirmed that increase in molecular weight of polyethylene glycol (PEG) as the pore forming agent in the phase inversion stage, increased the pore size, the amount of acrylic acid deposition on the membrane walls and pH-sensitivity. Also, an increase in grafting intensity decreased the pore sizes and increased their surface charges as well as amoxicillin separation. AFM analysis showed that surface roughness decreases which reflect the reduction in deposition of acrylic acid onto membrane surface valleys. Since the membrane pores are electrically charged, which was confirmed by zeta potential measurement, when the pH of solution increases, the amoxicillin separation by these pH-sensitive membranes increases. Finally, the amoxicillin separation of synthesized nanofiltration membranes at pH = 10 successfully reached relatively high amount of 91%, while acceptable flux of 108.31 h(-1) m(2) was maintained. The SEM images also confirmed increase in membrane pore sizes due to increase of PEG molecular weight."
According to the news editors, the research concluded: "The FUR analysis revealed that the amount of amoxicillin fouled on the membrane surface declined at higher pH due to high repulsion of amoxicillin by membrane."
For more information on this research see: Amoxicillin separation from pharmaceutical solution by pH sensitive nanofiltration membranes. Separation and Purification Technology, 2014;130():74-83. Separation and Purification Technology can be contacted at: Elsevier Science Bv, PO Box 211, 1000 Ae Amsterdam, Netherlands. (Elsevier - www.elsevier.com; Separation and Purification Technology - www.elsevier.com/wps/product/cws_home/600251)
Our news journalists report that additional information may be obtained by contacting M. Homayoonfal, Univ Tehran, Coll Engn, Sch Chem Engn, Tehran, Iran (see also Antibiotics).
Keywords for this news article include: Iran, Asia, Antiinfectives, Pharmaceuticals, Drugs, Tehran, Therapy, Ampicillin, Amoxicillin, Nanofiltration, Nanotechnology, Aminopenicillins, Sulfur Compounds, Emerging Technologies, Beta-Lactam Antibiotics
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