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Investigators from University of Illinois Have Reported New Data on Magnetic Resonance Imaging (Two-Dimensional Semi-LASER Correlation Spectroscopy...

July 25, 2014

Investigators from University of Illinois Have Reported New Data on Magnetic Resonance Imaging (Two-Dimensional Semi-LASER Correlation Spectroscopy with Well-Maintained Cross Peaks)

By a News Reporter-Staff News Editor at Health & Medicine Week -- Current study results on Medical Imaging have been published. According to news reporting originating from Chicago, Illinois, by NewsRx correspondents, research stated, "To demonstrate that the limited bandwidth of the second 90 degrees radiofrequency (RF) pulse in two-dimensional (2D) localized correlation spectroscopy (L-COSY) induces spatially dependent magnetization transfer that results in attenuated cross-peaks, and to propose a new 2D semi-adiabatically localized COSY sequence to solve this problem. Methods and Theory: A semi-localization by adiabatic selective refocusing (semi-LASER or sLASER) method was incorporated into the COSY sequence with the slice-selective first 90 degrees RF pulse and the non-slice-selective second 90 degrees RF pulse to form a new 2D sLASER localized COSY sequence, named 'sLASER-first-COSY,' to solve the problem of spatially dependent magnetization transfer."

Our news editors obtained a quote from the research from the University of Illinois, "Experiments were performed to verify the feasibility and advantages of sLASER-first-COSY sequence over a recently reported other sLASER COSY sequence with a slice-selective second 90 degrees RF pulse, named ' sLASER-last-COSY'. Phantom, ex vivo, and in vivo human brain experiments demonstrated that sLASER-first-COSY yielded stronger cross peaks and higher ratios of cross peak volumes to diagonal peak volumes than sLASER-last-COSY."

According to the news editors, the research concluded: "As COSY relies on the cross peaks to obtain larger dispersion of peaks for quantification, the new sLASER-first-COSY sequence yielding well-maintained cross peaks will facilitate more reliable and accurate quantification of metabolites with coupled spin systems."

For more information on this research see: Two-Dimensional Semi-LASER Correlation Spectroscopy with Well-Maintained Cross Peaks. Magnetic Resonance in Medicine, 2014;72(1):26-32. Magnetic Resonance in Medicine can be contacted at: Wiley-Blackwell, 111 River St, Hoboken 07030-5774, NJ, USA. (Wiley-Blackwell -; Magnetic Resonance in Medicine -

The news editors report that additional information may be obtained by contacting M.J. Lin, University of Illinois, Dept. of Bioengn, Chicago, IL 60612, United States. Additional authors for this research include A. Kumar and S.L. Yang (see also Medical Imaging).

Keywords for this news article include: Chicago, Illinois, United States, Medical Imaging, North and Central America

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Source: Health & Medicine Week

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