Investigators from Gettysburg College Report New Data on Proteomics (Homing Peptide-Conjugated Gold Nanorods: The Effect of Amino Acid Sequence Display on Nanorod Uptake and Cellular Proliferation)
By a News Reporter-Staff News Editor at Cancer Weekly -- Data detailed on Proteomics have been presented. According to news reporting originating from Gettysburg, Pennsylvania, by NewsRx correspondents, research stated, "Gold nanorods (GNRs) have attracted significant interest in the field of medicine as theranostic agents for both imaging and photothermal ablation of cancerous cells/tissues. Targeting theranostic GNRs specifically to cancer cells is necessary to enhance treatment efficacy and minimize undesired side effects."
Our news editors obtained a quote from the research from Gettysburg College, "In this study, targeting functionalized GNR to EphA2 receptors that are overexpressed on prostate cancer cells was investigated as a strategy to achieve enhanced GNR uptake by cancer cells. In addition, the influence of targeting peptide orientation on functionalized GNR uptake by PC-3 cells was explored. GNRs of aspect ratio 4 were functionalized with an EphA2 homing peptide, YSA, using a layer-by-layer polypeptide wrapping approach. In parallel, an analogous population of YSA-modified GNRs, which display a reversed YSA peptide, with the N- and C- termini reversed, was also prepared. GC-MS analysis of the YSA-GNRs indicated that functionalized GNRs displayed approximately 3000 peptides/GNR. The functionalized GNRs remained well-dispersed in biological media for short times (
According to the news editors, the research concluded: "Overall, the polypeptide LBL deposition technique provides a facile route to target nanoparticles to overexpressed cellular receptors, with the caveat that the specific orientation and display of the targeting moiety plays a critical role in the interaction between the nanoparticle and the cell."
For more information on this research see: Homing Peptide-Conjugated Gold Nanorods: The Effect of Amino Acid Sequence Display on Nanorod Uptake and Cellular Proliferation. Bioconjugate Chemistry, 2014;25(6):1162-1171. Bioconjugate Chemistry can be contacted at: Amer Chemical Soc, 1155 16TH St, NW, Washington, DC 20036, USA. (American Chemical Society - www.acs.org; Bioconjugate Chemistry - www.pubs.acs.org/journal/bcches)
The news editors report that additional information may be obtained by contacting A.M. Alkilany, Gettysburg College, Dept. of Chem, Gettysburg, PA 17325, United States. Additional authors for this research include S.P. Boulos, S.E. Lohse, L.B. Thompson and C.J. Murphy (see also Proteomics).
Keywords for this news article include: Cancer, Oncology, Peptides, Proteins, Gettysburg, Proteomics, Amino Acids, Pennsylvania, United States, North and Central America
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