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Investigators from Biogen Idec, Inc. Zero in on Biotechnology (Verification of energy dissipation rate scalability in pilot and production scale...

July 23, 2014



Investigators from Biogen Idec, Inc. Zero in on Biotechnology (Verification of energy dissipation rate scalability in pilot and production scale bioreactors using computational fluid dynamics)

By a News Reporter-Staff News Editor at Biotech Week -- Data detailed on Technology have been presented. According to news reporting originating from Cambridge, Massachusetts, by NewsRx correspondents, research stated, "Suspension mammalian cell cultures in aerated stirred tank bioreactors are widely used in the production of monoclonal antibodies. Given that production scale cell culture operations are typically performed in very large bioreactors ( 10,000 L), bioreactor scale-down and scale-up become crucial in the development of robust cell-culture processes."

Our news editors obtained a quote from the research from Biogen Idec, Inc., "For successful scale-up and scale-down of cell culture operations, it is important to understand the scale-dependence of the distribution of the energy dissipation rates in a bioreactor. Computational fluid dynamics (CFD) simulations can provide an additional layer of depth to bioreactor scalability analysis. In this communication, we use CFD analyses of five bioreactor configurations to evaluate energy dissipation rates and Kolmogorov length scale distributions at various scales. The results show that hydrodynamic scalability is achievable as long as major design features (# of baffles, impellers) remain consistent across the scales."

According to the news editors, the research concluded: "Finally, in all configurations, the mean Kolmogorov length scale is substantially higher than the average cell size, indicating that catastrophic cell damage due to mechanical agitation is highly unlikely at all scales."

For more information on this research see: Verification of energy dissipation rate scalability in pilot and production scale bioreactors using computational fluid dynamics. Biotechnology Progress, 2014;30(3):760-764. Biotechnology Progress can be contacted at: Wiley-Blackwell, 111 River St, Hoboken 07030-5774, NJ, USA. (American Chemical Society - www.acs.org; Biotechnology Progress - www.pubs.acs.org/journal/bipret)

The news editors report that additional information may be obtained by contacting C. Johnson, Biogen Idec Inc, Global Engn Sci, Cambridge Center 10, Cambridge, MA 02142, United States. Additional authors for this research include V. Natarajan and C. Antoniou (see also Technology).

Keywords for this news article include: Cambridge, Technology, Massachusetts, United States, North and Central America

Our reports deliver fact-based news of research and discoveries from around the world. Copyright 2014, NewsRx LLC


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Source: Biotech Week


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