Investigators at Wayne State University Report New Data on Nanocarriers (Polymeric nanocarriers for transport modulation across the pulmonary epithelium: dendrimers, polymeric nanoparticles, and their nanoblends)
By a News Reporter-Staff News Editor at Drug Week -- Investigators publish new report on Nanocarriers. According to news reporting originating from Detroit, Michigan, by NewsRx correspondents, research stated, "The purpose of this study was to (a) Determine the cellular transport and uptake of amine-terminated generation 3 (G3) poly(amido amine) (PAMAM) dendrimers across an in vitro model of the pulmonary epithelium, and the ability to modulate their transport by forming nanoblends of the dendrimers with biodegradable solid polymeric nanoparticles (NPs) and (b) to formulate dendrimer nanocarriers in portable oral inhalation devices and evaluate their aerosol characteristics. To that end, fluorescein isothiocyanate (FITC)-labeled G3 PAMAM dendrimer nanocarriers (DNCs) were synthesized, and also encapsulated within poly lactide-co-glycolide nanoparticles (NPs)."
Our news editors obtained a quote from the research from Wayne State University, "Transport and uptake of both DNCs encapsulated within NPs (nanoblends) and unencapsulated DNCs were tracked across polarized monolayers of airway epithelial cells, Calu-3. DNCs were also formulated as core-shell microparticles in pressurized metered-dose inhalers (pMDIs) and their aerodynamic properties evaluated by Andersen cascade impaction. The apparent permeability of DNCs across the airway epithelial model was similar to that of a paracellular marker of comparable molar mass--order of 10(-7) cm s(-1). The transport and cellular internalization of the DNCs can be modulated by formulating them as nanoblends. The transport of the DNCs across the lung epithelium was completely suppressed within the time of the experiment (5 h) when formulated as blends. The encapsulation also prevents saturation of the cellular internalization profile."
According to the news editors, the research concluded: "Nanoblending may be a potential strategy to modulate the rate of transport and cellular uptake of DNCs, and thus be used as a design strategy to achieve enhanced local or systemic drug delivery."
For more information on this research see: Polymeric nanocarriers for transport modulation across the pulmonary epithelium: dendrimers, polymeric nanoparticles, and their nanoblends. The Aaps Journal [electronic Resource], 2014;16(3):522-38. The Aaps Journal [electronic Resource] can be contacted at: Springer, 233 Spring Street, New York, NY 10013, USA (see also Nanocarriers).
The news editors report that additional information may be obtained by contacting B. Bharatwaj, Chemical Engineering and Materials Science, College of Engineering, Wayne State University, Detroit, Michigan, 48202, United States. Additional authors for this research include R. Dimovski, D.S. Conti and S.R da Rocha.
Publisher contact information for the The Aaps Journal [electronic Resource] is: Springer, 233 Spring Street, New York, NY 10013, USA.
Keywords for this news article include: Detroit, Michigan, Nanocarriers, Nanoparticle, United States, Nanotechnology, Emerging Technologies, North and Central America.
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