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Investigators at University of North Texas Report Findings in Non-Small Cell Lung Cancer (Enhanced Toxicity of Cisplatin with Chemosensitizer...

July 23, 2014



Investigators at University of North Texas Report Findings in Non-Small Cell Lung Cancer (Enhanced Toxicity of Cisplatin with Chemosensitizer Phenethyl Isothiocyanate toward Non-Small Cell Lung Cancer Cells When Delivered in Liposomal ...)

By a News Reporter-Staff News Editor at Biotech Week -- Fresh data on Oncology are presented in a new report. According to news reporting from Fort Worth, Texas, by NewsRx journalists, research stated, "Naturally occurring phenethyl isothiocyanate (PEITC) was previously shown to sensitize human non-small cell lung cancer (NSCLC) cells to the platinum anticancer drug cisplatin (CDDP)."

The news correspondents obtained a quote from the research from the University of North Texas, "Here, CDDP and PEITC were encapsulated in approximately 130 nm liposomes composed of 1,2-distearoyl-sn-glycero-3-phosphocholine (DSPC) and L-alpha-phosphatidylglycerol (EPG). The liposomal formulation enhanced the toxicity of this doublet (1:2 molar ratio of CDDP/PEITC) toward NCI-H596 NSCLC cells; the percent survival of cells was 30.2 +/- 6.2% after treatment with the nanoparticle formulation, compared to 50.9 +/- 3.5% when administered together free."

According to the news reporters, the research concluded: "Thus, such a treatment modality could prove useful in the clinic for the treatment of NSCLC."

For more information on this research see: Enhanced Toxicity of Cisplatin with Chemosensitizer Phenethyl Isothiocyanate toward Non-Small Cell Lung Cancer Cells When Delivered in Liposomal Nanoparticles. Chemical Research in Toxicology, 2014;27(6):946-948. Chemical Research in Toxicology can be contacted at: Amer Chemical Soc, 1155 16TH St, NW, Washington, DC 20036, USA. (American Chemical Society - www.acs.org; Chemical Research in Toxicology - www.pubs.acs.org/journal/crtoec)

Our news journalists report that additional information may be obtained by contacting Y.T. Yang, University of North Texas, Hlth Sci Center, Univ North Texas Syst Coll Pharm, Dept. of Pharmaceut Sci, Fort Worth, TX 76107, United States. Additional authors for this research include Y. Shi, M. Jay and A.J. Di Pasqua (see also Oncology).

Keywords for this news article include: Antineoplastics, Pharmaceuticals, Texas, Drugs, Therapy, Oncology, Cisplatin, Fort Worth, Isocyanates, Nanoparticle, United States, Lung Neoplasms, Nanotechnology, Isothiocyanates, Sulfur Compounds, Alkylating Agents, Chlorine Compounds, Nitrogen Compounds, Platinum Compounds, Emerging Technologies

Our reports deliver fact-based news of research and discoveries from around the world. Copyright 2014, NewsRx LLC


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Source: Biotech Week


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