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Investigators at Shenyang University Discuss Findings in Proinsulin (Thiolated Eudragit-based Nanoparticles for Oral Insulin Delivery: Preparation,...

July 22, 2014



Investigators at Shenyang University Discuss Findings in Proinsulin (Thiolated Eudragit-based Nanoparticles for Oral Insulin Delivery: Preparation, Characterization, and Evaluation Using Intestinal Epithelial Cells In Vitro)

By a News Reporter-Staff News Editor at Life Science Weekly -- Current study results on Peptide Proteins have been published. According to news reporting originating from Shenyang, People's Republic of China, by NewsRx correspondents, research stated, "This work deals with the synthesis of insulin loaded nanoparticles (NPs) composed of thiolated Eudragit L100 (Eul-cys) and reduced glutathione (GSH) as potential nanocarriers for oral delivery of insulin. Perfectly spherical NPs with an average particle size of nearly 200-300 nm are prepared."

Our news editors obtained a quote from the research from Shenyang University, "The insulin release from Eul-cys/GSH and Eul-cys NPs in PBS (pH 7.4) shows that GSH can slightly decrease the release rate of insulin. Eul-cys in combination with GSH or sodium caprate (SC) is evaluated for its permeation enhancing effect of FITC-insulin using the Caco-2 monolayer and Caco-2/HT29-MTX co-cultured cells models. SC results in greater permeation enhancement compared to GSH. However, GSH proves to be less toxic."

According to the news editors, the research concluded: "Paracellular transport of insulin represents the main mechanism by which the NPs facilitate insulin permeation through the intestinal epithelium, whereas a number of NPs are also taken up by the cells and release insulin within the cells."

For more information on this research see: Thiolated Eudragit-based Nanoparticles for Oral Insulin Delivery: Preparation, Characterization, and Evaluation Using Intestinal Epithelial Cells In Vitro. Macromolecular Bioscience, 2014;14(6):842-852. Macromolecular Bioscience can be contacted at: Wiley-V C H Verlag Gmbh, Boschstrasse 12, D-69469 Weinheim, Germany. (Wiley-Blackwell - www.wiley.com/; Macromolecular Bioscience - onlinelibrary.wiley.com/journal/10.1002/(ISSN)1616-5195)

The news editors report that additional information may be obtained by contacting Y. Zhang, Shenyang Univ, Normal College, Shenyang 110044, People's Republic of China. Additional authors for this research include X.L. Du, Y. Zhang, G.F. Li, C.F. Cai, J.H. Xu and X. Tang (see also Peptide Proteins).

Keywords for this news article include: Asia, Shenyang, Proinsulin, Nanoparticle, Nanotechnology, Epithelial Cells, Peptide Hormones, Peptide Proteins, Emerging Technologies, People's Republic of China

Our reports deliver fact-based news of research and discoveries from around the world. Copyright 2014, NewsRx LLC


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Source: Life Science Weekly


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