Investigators at Nagasaki University Graduate School of Biomedical Sciences Target Intracellular Space (D-glucosamine conjugation accelerates the labeling efficiency of quantum dots in osteoblastic cells)
By a News Reporter-Staff News Editor at Life Science Weekly -- Current study results on Intracellular Space have been published. According to news reporting originating from Nagasaki, Japan, by NewsRx correspondents, research stated, "Quantum dots (QDs) are useful imaging tools in the medical and biological fields due to their optical properties, such as a high fluorescence intensity, remarkable resistance to photobleaching, broad absorption spectra, and narrow emission spectra. This is the first study to investigate the uptake of carboxylated QDs conjugated with D-glucosamine (core size: approximately 3 nm, final modified size: 20-30 nm) into cultured osteoblastic cells."
Our news editors obtained a quote from the research from the Nagasaki University Graduate School of Biomedical Sciences, "The QDs attached to the cell surface and were transported into the cytoplasm within approximately three hours of culture, whose process was clearly demonstrated using specific fluorescent staining of the cell membrane. Although the intranuclear distribution was not observed, a dramatic decrease in the transfer of quantum dots into the cytoplasm was recognized after approximately seven days of culture. Other interesting phenomena include the escape of the quantum dots from lysosomes in the cytoplasm, as confirmed by the merging of both QD fluorescence and specific fluorescent staining of lysosomes in the cytoplasm."
According to the news editors, the research concluded: "These findings suggest that D-glucosamine conjugation enhances proton absorption in acid organelles and promotes the lysosomal escape of QDs."
For more information on this research see: D-glucosamine conjugation accelerates the labeling efficiency of quantum dots in osteoblastic cells. Biomed Research International, 2014;2014():821607 (see also Intracellular Space).
The news editors report that additional information may be obtained by contacting K. Igawa, Dept. of Cariology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki 852-8588, Japan. Additional authors for this research include M.F. Xie, H. Ohba, S. Yamada and Y. Hayashi.
Keywords for this news article include: Asia, Japan, Nagasaki, Cytoplasm, Osteoblasts, Quantum Dots, Quantum Physics, Intracellular Space, Connective Tissue Cells.
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