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Investigators at Aarhus University Target Molecular Biology (Challenges and opportunities in fractionation of recombinant human mannan-binding lectin)

July 22, 2014



By a News Reporter-Staff News Editor at Life Science Weekly -- Fresh data on Life Science Research are presented in a new report. According to news reporting originating from Aarhus, Denmark, by NewsRx editors, the research stated, "Mannan-binding lectin is an oligomeric protein of the innate immune system. Both natural MBL as well as recombinant protein is a heterogeneous composition of oligomers containing from two up to at least eight structural units."

Our news editors obtained a quote from the research from Aarhus University, "Recombinant synthesis in mammalian cell lines often leads to a composition containing small oligomers not abundant in MBL from natural sources such as human plasma. Here, two procedures for fractionation of MBL oligomers are described. In one case, affinity chromatography is employed to enrich the abundance of large MBL oligomers to produce a composition of oligomers resembling natural MBL. In a second case, large-volume ion exchange chromatography is employed to separate these oligomers into fractions with an enhanced size homogeneity."

According to the news editors, the research concluded: "Finally, a well-established procedure for estimating the MBL protein concentration is detailed."

For more information on this research see: Challenges and opportunities in fractionation of recombinant human mannan-binding lectin. Methods In Molecular Biology, 2014;1100():109-21 (see also Life Science Research).

The news editors report that additional information may be obtained by contacting B.i.o.p.h.y.s.i.c.a.l. Immunology Laboratory, Dept. of Biomedicine, The Lundbeck Foundation Nanomedicine Center for Individualized Management of Tissue Damage and Regeneration and Interdisciplinary Nanoscience Center, Aarhus University, Aarhus, Denmark.

Keywords for this news article include: Aarhus, Europe, Denmark, Life Science Research.

Our reports deliver fact-based news of research and discoveries from around the world. Copyright 2014, NewsRx LLC


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Source: Life Science Weekly


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