Findings on Stem Cells Reported by Researchers at Technical University [A novel strontium(II)-modified calcium phosphate bone cement stimulates human-bone-marrow-derived mesenchymal stem cell proliferation and osteogenic differentiation in vitro]
By a News Reporter-Staff News Editor at Biotech Week -- Current study results on Stem Cell Research have been published. According to news reporting from Dresden, Germany, by NewsRx journalists, research stated, "In the present study, the in vitro effects of novel strontium-modified calcium phosphate bone cements (SrCPCs), prepared using two different approaches on human-bone-marrow-derived mesenchymal stem cells (hMSCs), were evaluated. Strontium ions, known to stimulate bone formation and therefore already used in systemic osteoporosis therapy, were incorporated into a hydroxyapatite-forming calcium phosphate bone cement via two simple approaches: incorporation of strontium carbonate crystals and substitution of Ca(2+) by Sr(2+) ions during cement setting."
The news correspondents obtained a quote from the research from Technical University, "All modified cements released 0.03-0.07 mM Sr(2+) under in vitro conditions, concentrations that were shown not to impair the proliferation or osteogenic differentiation of hMSCs. Furthermore, strontium modification led to a reduced medium acidification and Ca(2+) depletion in comparison to the standard calcium phosphate cement. In indirect and direct cell culture experiments with the novel SrCPCs significantly enhanced cell proliferation and differentiation were observed."
According to the news reporters, the research concluded: "The SrCPCs described here could be beneficial for the local treatment of defects, especially in the osteoporotic bone."
For more information on this research see: A novel strontium(II)-modified calcium phosphate bone cement stimulates human-bone-marrow-derived mesenchymal stem cell proliferation and osteogenic differentiation in vitro. Acta Biomaterialia, 2013;9(12):9547-57. (Elsevier - www.elsevier.com; Acta Biomaterialia - www.elsevier.com/wps/product/cws_home/702994)
Our news journalists report that additional information may be obtained by contacting M. Schumacher, Centre for Translational Bone, Joint and Soft Tissue Research, Medical Faculty and University Hospital, Technische Universitat Dresden, Dresden, Germany. Additional authors for this research include A. Lode, A. Helth and M. Gelinsky (see also Stem Cell Research).
Keywords for this news article include: Tissue Engineering, Biomedical Engineering, Biomedical and Dental Materials, Biomedicine, Europe, Anions, Dresden, Germany, Bone Marrow, Bone Cements, Bone Research, Immune System, Bioengineering, Phosphoric Acids, Calcium Compounds, Calcium Phosphates, Cell Proliferation, Stem Cell Research, Inorganic Chemicals.
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