Findings on Biochemistry Reported by Investigators at Hebrew University [Anti-proliferative Activity of Nano-Formulated Phenolato Titanium(IV) Complexes Against Cancer Cells]
By a News Reporter-Staff News Editor at Cancer Weekly -- Current study results on Life Science Research have been published. According to news reporting out of Jerusalem, Israel, by NewsRx editors, research stated, "Nanoparticles of titanium(IV) complexes of phenolato ligands were formed and evaluated for cytotoxicity toward human HT-29 colon cancer, murine T-25 lymphoma, and murine HU-2 multidrug-resistant (MDR) cells. The nano-formulation, besides increasing the complexes shelf lives, is particularly efficient in overcoming limitations in solubility and cell-penetration, thus enhancing biological accessibility; large complexes that were inactive when measured in a non-formulated form showed marked activity when nano-formulated."
Our news journalists obtained a quote from the research from Hebrew University, "For active and accessible small complexes, the effect of the formulation was negligible. Most complexes showed similar activity toward MDR cells and their drug-sensitive analogues, further increasing their therapeutic potential. An exception is a particularly hydrophobic complex, which is presumably more accessible to interaction with the membrane ABCB1 (MDR1) transporter active in the multidrug resistance of HU-2 cells."
According to the news editors, the research concluded: "The most efficient compound is a mononuclear complex of a single hexadentate ligand, combining particularly high activity and hydrolytic stability with accessibility aided by the nano-formulation."
For more information on this research see: Anti-proliferative Activity of Nano-Formulated Phenolato Titanium(IV) Complexes Against Cancer Cells. Chemmedchem, 2014;9(6):1294-1298. Chemmedchem can be contacted at: Wiley-V C H Verlag Gmbh, Boschstrasse 12, D-69469 Weinheim, Germany. (Wiley-Blackwell - www.wiley.com/; Chemmedchem - onlinelibrary.wiley.com/journal/10.1002/(ISSN)1860-7187)
Our news journalists report that additional information may be obtained by contacting S. Meker, Hebrew University of Jerusalem, Alexander Silberman Inst Life Sci, Dept. of Cell & Dev Biol, IL-91904 Jerusalem, Israel. Additional authors for this research include K. Margulis-Goshen, E. Weiss, O. Braitbard, J. Hochman, S. Magdassi and E.Y. Tshuva (see also Life Science Research).
Keywords for this news article include: Asia, Israel, Cancer, Oncology, Titanium, Jerusalem, Light Metals, Life Science Research
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