News Column

Findings from Zhengzhou University in Fullerenes Reported (A fullerene-based multi-functional nanoplatform for cancer theranostic applications)

July 22, 2014

By a News Reporter-Staff News Editor at Cancer Weekly -- Current study results on Fullerenes have been published. According to news reporting from Zhengzhou, People's Republic of China, by NewsRx journalists, research stated, "Recently, nanomaterials with multiple functions, such as drug carrier, MRI and optical imaging, photothermal therapy etc, have become more and more popular in the domain of cancer research. In this study, a C60-IONP nanocomposite is synthesized via decorating iron oxide nanoparticles (IONP) onto fullerene (C60) and then functionalized by polyethylene glycol (PEG2000), giving C60-IONP-PEG with excellent stability in physiological solutions, finally folic acid (FA), a widely used tumor targeting molecule, was linked to C60-IONP-PEG in order to obtain an active tumor targeting effect to MCF-7 cells and malignant tumor in mice models."

The news correspondents obtained a quote from the research from Zhengzhou University, "Herein, a hybrid nanoplatform with multi-functional characteristics for cancer diagnosis, photodynamic therapy (PDT), radiofrequency (RF) thermal therapy (RTT) and magnetic targeting applications was developed and explored its biofunctions in vitro and in vivo. C60-IONP-PEG-FA showed neglectable toxicity, not only served as a powerful tumor diagnostic magnetic resonance imaging (MRI) contrast agent, but also as a strong photosensitizer and powerful agent for photothermal ablation of tumor, furthermore a remarkable synergistic enhancement of PDT combination with RTT was also observed during the treatment both in vitro and in vivo. Moreover, the multi-functional nanoplatform also could selectively kill cancer cells in highly localized regions via the excellent active tumor targeting and magnetic targeted abilities."

According to the news reporters, the research concluded: "This work showed the multi-functional C60-IONP-PEG-FA nanoplatform had a great potential for cancer theranostic applications."

For more information on this research see: A fullerene-based multi-functional nanoplatform for cancer theranostic applications. Biomaterials, 2014;35(22):5771-84. (Elsevier -; Biomaterials -

Our news journalists report that additional information may be obtained by contacting J. Shi, School of Pharmaceutical Sciences, Zhengzhou University, 100 Kexue Avenue, Zhengzhou 450001, People's Republic of China. Additional authors for this research include L. Wang, J. Gao, Y. Liu, J. Zhang, R. Ma, R. Liu and Z. Zhang (see also Fullerenes).

Keywords for this news article include: Asia, Cancer, Carbon, Therapy, Oncology, Zhengzhou, Fullerenes, Nanotechnology, Emerging Technologies, People's Republic of China.

Our reports deliver fact-based news of research and discoveries from around the world. Copyright 2014, NewsRx LLC

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Source: Cancer Weekly

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