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Findings from Yonsei University Provides New Data about Gene Therapy (Sticky "Delivering-From" Strategies Using Viral Vectors for Efficient Human...

July 24, 2014



Findings from Yonsei University Provides New Data about Gene Therapy (Sticky "Delivering-From" Strategies Using Viral Vectors for Efficient Human Neural Stem Cell Infection by Bioinspired Catecholamines)

By a News Reporter-Staff News Editor at Gene Therapy Weekly -- Research findings on Biotechnology are discussed in a new report. According to news reporting out of Seoul, South Korea, by NewsRx editors, research stated, "Controlled release of biosuprastructures, such as viruses, from surfaces has been a challenging task in providing efficient ex vivo gene delivery. Conventional controlled viral release approaches have demonstrated low viral immobilization and burst release, inhibiting delivery efficiency."

Our news journalists obtained a quote from the research from Yonsei University, "Here, a highly powerful substrate-mediated viral delivery system was designed by combining two key components that have demonstrated great potential in the fields of gene therapy and surface chemistry, respectively: adeno-associated viral (AAV) vectors and adhesive catecholamine surfaces. The introduction of a nanoscale thin coating of catecholamines, poly(norepinephrine) (pNE) or poly(dopamine) (pDA) to provide AAV adhesion followed by human neural stem cell (hNSC) culture on sticky solid surfaces exhibited unprecedented results: approximately 90% loading vs 25% (AAV_bare surface), no burst release, sustained release at constant rates, approximately 70% infection vs 20% (AAV_bare surface), and rapid internalization. Importantly, the sticky catecholamine-mediated AAV delivery system successfully induced a physiological response from hNSCs, cellular proliferation by a single-shot of AAV encoding fibroblast growth factor-2 (FGF-2), which is typically achieved by multiple treatments with expensive FGF-2 proteins."

According to the news editors, the research concluded: "By combining the adhesive material-independent surface functionalization characters of pNE and pDA, this new sticky 'delivering-from' gene delivery platform will make a significant contribution to numerous fields, including tissue engineering, gene therapy, and stem cell therapy."

For more information on this research see: Sticky "Delivering-From" Strategies Using Viral Vectors for Efficient Human Neural Stem Cell Infection by Bioinspired Catecholamines. ACS Applied Materials & Interfaces, 2014;6(11):8288-8294. ACS Applied Materials & Interfaces can be contacted at: Amer Chemical Soc, 1155 16TH St, NW, Washington, DC 20036, USA. (American Chemical Society - www.acs.org; ACS Applied Materials & Interfaces - www.pubs.acs.org/journal/aamick)

Our news journalists report that additional information may be obtained by contacting E. Kim, Yonsei University, Coll Med, Dept. of Pediat, Seoul 120749, South Korea. Additional authors for this research include S. Lee, S. Hong, G. Jin, M. Kim, K.I. Park, H. Lee and J.H. Jang (see also Biotechnology).

Keywords for this news article include: Asia, Biotechnology, Tissue Engineering, Seoul, Viral, Virus, South Korea, Gene Therapy, Bioengineering, Catecholamines, Biogenic Monoamines

Our reports deliver fact-based news of research and discoveries from around the world. Copyright 2014, NewsRx LLC


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Source: Gene Therapy Weekly


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