Findings from University of Tehran Update Understanding of Breast Cancer (An electrochemical immunosensor for detection of a breast cancer biomarker based on antiHER2-iron oxide nanoparticle bioconjugates)
By a News Reporter-Staff News Editor at Cancer Weekly -- Research findings on Oncology are discussed in a new report. According to news originating from Tehran, Iran, by NewsRx correspondents, research stated, "A label free immunosensor was designed for ultra-detection of human epidermal growth factor receptor 2 (HER2) in real samples using a differential pulse voltammetry (DPV) method. In a separate process, antiHER2 antibodies were attached to iron oxide nanoparticles (Fe3O4 NPs) to form stable bioconjugates which were later laid over the gold electrode surface."
Our news journalists obtained a quote from the research from the University of Tehran, "In this way, by the advantage of their long terminals, the bioconjugates provided the most possible space for the immuno-reaction between biomolecules. Under optimal conditions, the immunosensor was responsive to HER2 concentrations over the ranges of 0.01-10 ng mL(-1) and 10-100 ng mL(-1) linearly and benefited from a satisfactory detection limit as low as 0.995 pg mL(-1) and a favorable sensitivity as sharp as 5.921 ?A mL ng(-1). The reliability of the method in clinical analysis was proved by successful quantization of HER2 levels in serum samples obtained from patients."
According to the news editors, the research concluded: "Furthermore, the precision and the stability of the method were evaluated and verified to be acceptable in immunoassay studies."
For more information on this research see: An electrochemical immunosensor for detection of a breast cancer biomarker based on antiHER2-iron oxide nanoparticle bioconjugates. Analyst, 2014;139(11):2858-66. (Royal Society of Chemistry - www.rsc.org/; Analyst - pubs.rsc.org/en/journals/journalissues/an)
The news correspondents report that additional information may be obtained from M. Emami, School of chemistry, University college of science, University of Tehran, Tehran, Iran. Additional authors for this research include M. Shamsipur, R. Saber and R. Irajirad (see also Oncology).
Keywords for this news article include: Iran, Asia, Tehran, Oncology, Chemistry, Breast Cancer, Women's Health, Electrochemical.
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