News Column

Findings from University of California Yields New Data on Strongyloidiasis (Bacteriophage-Fused Peptides for Serodiagnosis of Human Strongyloidiasis)

July 25, 2014



By a News Reporter-Staff News Editor at Health & Medicine Week -- Data detailed on Parasitic Diseases have been presented. According to news originating from Davis, California, by NewsRx correspondents, research stated, "Strongyloidiasis, a human intestinal infection caused by the nematode Strongyloides stercoralis, is frequently underdiagnosed and although its high prevalence is still a neglected parasitic disease because conventional diagnostic tests based on parasitological examination (presence of Strongyloides larvae in stool) are not sufficiently sensitive due to the low parasitic load and to the irregular larval output. There is an urgent need to improve diagnostic assays, especially for immunocompromised patients with high parasitic load as consequence of self-infection cycle, which can disseminate throughout the body, resulting in a potentially fatal hyperinfection syndrome often accompanied by sepsis or meningitis."

Our news journalists obtained a quote from the research from the University of California, "Methods/Principal Findings: We have performed Phage Display technology to select peptides that mimic S. stercoralis antigens, capable of detecting a humoral response in patients with strongyloidiasis. The peptides reactivity was investigated by Phage-ELISA through different panels of serum samples. We have successfully selected five peptides with significant immunoreactivity to circulating IgG from patients' sera with strongyloidiasis. The phage displayed peptides C9 and C10 presented the highest diagnostic potential (AUC >0.87) with excellent sensitivity (>85%) and good specificity (>77.5%), suggesting that some S. stercoralis antigens trigger systemic immune response. These novel antigens are interesting serum biomarkers for routine strongyloidiasis screenings due to the easy production and simple assay using Phage-ELISA."

According to the news editors, the research concluded: "Such markers may also present a promising application for therapeutic monitoring."

For more information on this research see: Bacteriophage-Fused Peptides for Serodiagnosis of Human Strongyloidiasis. Plos Neglected Tropical Diseases, 2014;8(5):104-112. Plos Neglected Tropical Diseases can be contacted at: Public Library Science, 1160 Battery Street, Ste 100, San Francisco, CA 94111, USA. (Public Library of Science - www.plos.org; Plos Neglected Tropical Diseases - www.plosntds.org)

The news correspondents report that additional information may be obtained from N.D. Feliciano, University of California, Dept. of Med Microbiol & Immunol, Davis, CA 95616, United States. Additional authors for this research include V.D. Ribeiro, F.D.A. Santos, P.T. Fujimura, H.T. Gonzaga, L.R. Goulart and J.M. Costa-Cruz (see also Parasitic Diseases).

Keywords for this news article include: Antigens, Davis, Viruses, Peptides, Proteins, California, Immunology, Amino Acids, United States, Bacteriophages, Strongyloidiasis, Biological Factors, Parasitic Diseases, North and Central America

Our reports deliver fact-based news of research and discoveries from around the world. Copyright 2014, NewsRx LLC


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Source: Health & Medicine Week


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