Findings from United States Department of Agriculture Broaden Understanding of Reproduction and Fertility (Role of stem cells in large animal genetic engineering in the TALENs-CRISPR era)
By a News Reporter-Staff News Editor at Life Science Weekly -- Current study results on Life Science Research have been published. According to news reporting from Beltsville, Maryland, by NewsRx journalists, research stated, "The establishment of embryonic stem cells (ESCs) and gene targeting technologies in mice has revolutionised the field of genetics. The relative ease with which genes can be knocked out, and exogenous sequences introduced, has allowed the mouse to become the prime model for deciphering the genetic code."
The news correspondents obtained a quote from the research from the United States Department of Agriculture, "Not surprisingly, the lack of authentic ESCs has hampered the livestock genetics field and has forced animal scientists into adapting alternative technologies for genetic engineering. The recent discovery of the creation of induced pluripotent stem cells (iPSCs) by upregulation of a handful of reprogramming genes has offered renewed enthusiasm to animal geneticists. However, much like ESCs, establishing authentic iPSCs from the domestic animals is still beset with problems, including (but not limited to) the persistent expression of reprogramming genes and the lack of proven potential for differentiation into target cell types both in vitro and in vivo. Site-specific nucleases comprised of zinc finger nucleases (ZFNs), transcription activator-like effector nucleases (TALENs) and clustered regulated interspaced short palindromic repeats (CRISPRs) emerged as powerful genetic tools for precisely editing the genome, usurping the need for ESC-based genetic modifications even in the mouse."
According to the news reporters, the research concluded: "In this article, in the aftermath of these powerful genome editing technologies, the role of pluripotent stem cells in livestock genetics is discussed."
For more information on this research see: Role of stem cells in large animal genetic engineering in the TALENs-CRISPR era. Reproduction Fertility and Development, 2014;26(1):65-73. Reproduction Fertility and Development can be contacted at: Csiro Publishing, 150 Oxford St, PO Box 1139, Collingwood, Victoria 3066, Australia (see also Life Science Research).
Our news journalists report that additional information may be obtained by contacting K.E. Park, Dept. of Agriculture ARS, Anim Biosci & Biotechnol Lab, Beltsville, MD 20705, United States.
Keywords for this news article include: Maryland, Livestock, Beltsville, Technology, Agriculture, United States, Genetic Engineering, Life Science Research, North and Central America
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