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Findings from National Taiwan University in Pharmacokinetics Reported (Novel lansoprazole-loaded nanoparticles for the treatment of gastric acid...

July 23, 2014



Findings from National Taiwan University in Pharmacokinetics Reported (Novel lansoprazole-loaded nanoparticles for the treatment of gastric acid secretion-related ulcers: in vitro and in vivo pharmacokinetic pharmacodynamic evaluation)

By a News Reporter-Staff News Editor at Biotech Week -- Current study results on Pharmacokinetics have been published. According to news originating from Taipei, Taiwan, by NewsRx correspondents, research stated, "The objective of this study is to combine nanoparticle design and enteric coating technique to sustain the delivery of an acid-labile drug, lansoprazole (LPZ), in the treatment of acid reflux disorders. Lansoprazole-loaded EudragitŪ RS100 nanoparticles (ERSNP-LPZ) as well as poly(lactic-co-glycolic acid) (PLGA) nanoparticles (PLGANP-LPZ) were prepared using a solvent evaporation/extraction method."

Our news journalists obtained a quote from the research from National Taiwan University, "The effects of nanoparticle charge and permeation enhancers on lansoprazole uptake was assessed in Caco-2 cells. The confocal microscopic images revealed the successful localization of nanoparticles in the cytoplasm of Caco-2 cells. The cellular uptake of positively charged Eudragit nanoparticles was significantly higher than that of negatively charged PLGA nanoparticles, which were enhanced by sodium caprate via the transcellular pathway. Both types of nanoparticles exhibited sustained drug release behavior in vitro."

According to the news editors, the research concluded: "The oral administration of enteric-coated capsules filled with nanoparticles sustained and prolonged the LPZ concentration up to 24 h in ulcer-induced Wistar rats, and 92.4% and 89.2% of gastric ulcers healed after a 7-day treatment with either EC-ERSNP1010-Na caprate or EC-PLGANP1005-Na caprate, respectively."

For more information on this research see: Novel lansoprazole-loaded nanoparticles for the treatment of gastric acid secretion-related ulcers: in vitro and in vivo pharmacokinetic pharmacodynamic evaluation. The Aaps Journal [electronic Resource], 2014;16(3):361-72. The Aaps Journal [electronic Resource] can be contacted at: Springer, 233 Spring Street, New York, NY 10013, USA (see also Pharmacokinetics).

The news correspondents report that additional information may be obtained from M. Alai, Graduate Institute of Pharmaceutical Sciences, School of Pharmacy, National Taiwan University, F 12 NO 1 Jen Ai Rd Sec 1, Taipei, 100, Taiwan.

The publisher's contact information for the The Aaps Journal [electronic Resource] is: Springer, 233 Spring Street, New York, NY 10013, USA.

Keywords for this news article include: Asia, Pharmaceuticals, Drugs, Taipei, Taiwan, Therapy, Gastric Acid, Nanoparticle, Nanotechnology, Gastroenterology, Gastrointestinal, Pharmacodynamics, Pharmacokinetics, Emerging Technologies.

Our reports deliver fact-based news of research and discoveries from around the world. Copyright 2014, NewsRx LLC


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Source: Biotech Week


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