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Findings from King's College Provides New Data about Stem Cells (Stem Cells Accumulate on a Decellularized Arterial Xenograft In Vivo)

July 23, 2014

By a News Reporter-Staff News Editor at Biotech Week -- Investigators publish new report on Stem Cell Research. According to news reporting originating from London, United Kingdom, by NewsRx correspondents, research stated, "Surgical interest in complete arterial revascularization is expanding, but some patients lack suitable conduits for this goal. The field of stem cell biology is rapidly expanding and, together with the concepts of tissue engineering, offers the promise of growing autologous grafts in the laboratory."

Our news editors obtained a quote from the research from King's College, "We aim to develop a model using human arteries as vascular grafts in a murine model and to assess the cellular accumulation on these grafts. Human arterial samples were collected and decellularized using an ionic detergent. These vessel scaffolds were then used as grafts in an in vivo mouse model, and the cellular accumulation on them was examined histologically and by cell culture with assessment of their physiologic properties. Left internal mammary artery branches were fully decellularized and successfully implanted into a murine model. Grafts were repopulated by cells expressing stem cell markers cluster of differentiation 34 and stage-specific embryonic antigen, and subsequently expressed markers of mature endothelial and smooth muscle cells (cluster of differentiation 31, calponin, and myosin heavy chain). The migratory capacity of the cultured cells was significantly higher than that of mouse smooth muscle cells (p < 0.001). We describe the successful use of human arteries in a murine graft model, allowing the study of repopulation. Decellularized grafts are repopulated by cells expressing stem cell markers and subsequently express smooth muscle and endothelial cell markers."

According to the news editors, the research concluded: "This model has the potential to be used for further development of laboratory-grown vascular grafts."

For more information on this research see: Stem Cells Accumulate on a Decellularized Arterial Xenograft In Vivo. Annals of Thoracic Surgery, 2014;97(6):2104-2110. Annals of Thoracic Surgery can be contacted at: Elsevier Science Inc, 360 Park Ave South, New York, NY 10010-1710, USA. (Elsevier -; Annals of Thoracic Surgery -

The news editors report that additional information may be obtained by contacting S.G. Jones, Kings Coll London, James Black Center, British Heart Fdn, Center Excellence, London, United Kingdom. Additional authors for this research include Y.H. Hu, Q.B. Xu and M. Jahangiri (see also Stem Cell Research).

Keywords for this news article include: Tissue Engineering, London, Europe, United Kingdom, Stem Cell Research

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Source: Biotech Week

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