Data from Institute of Medical Technology Provide New Insights into Essential Amino Acids (Surface Modification with Dopamine and Heparin/Poly-L-Lysine Nanoparticles Provides a Favorable Release Behavior for the Healing of Vascular Stent Lesions)
By a News Reporter-Staff News Editor at Life Science Weekly -- Investigators publish new report on Essential Amino Acids. According to news reporting out of Beijing, People's Republic of China, by NewsRx editors, research stated, "Surface biofunctional modification of coronary artery stents to prevent thrombosis and restenosis formation, as well as accelerate endothelialization, has become a new hot spot. However, bioactive coatings on implants are not yet sufficiently developed for long-term activity, as they quickly lose efficiency in vivo and finally fail."
Our news journalists obtained a quote from the research from the Institute of Medical Technology, "On the basis of a novel time-ordered concept of biofunctionality for vascular stents, heparin/poly L-lysine nanoparticle (NP) was developed and immobilized on a polydopamine-coated titanium surface, with the aim of regulating and maintaining the intravascular biological response within the normal range after biomaterial implantation. An in vitro dynamic release model was established to mimic the blood flow condition in vivo with three phases: (1) An early phase (1-7 days) with release of predominantly anticoagulant and anti-inflammatory substances and to a minor degree antiproliferative effects against smooth muscle cells (SMCs); (2) this is followed by a phase (7-14 days) of supported endothelial cell (ECs) proliferation and suppressed SMC proliferation with persisting high antithrombogenicity and anti-inflammatory properties of the surface. (3) Finally, a stable stage (14-28 days) with adequate biomolecules on the surface that maintain hemocompatibility and anti inflammation as well as inhibit SMCs proliferation and promote ECs growth. In vivo animal tests further confirmed that the NP-modified surface provides a favorable release behavior to apply a stage-adjusted remedy."
According to the news editors, the research concluded: "We suggested that these observations provide important guidance and potential means for reasonable and suitable platform construction on a stent surface."
For more information on this research see: Surface Modification with Dopamine and Heparin/Poly-L-Lysine Nanoparticles Provides a Favorable Release Behavior for the Healing of Vascular Stent Lesions. ACS Applied Materials & Interfaces, 2014;6(11):8729-8743. ACS Applied Materials & Interfaces can be contacted at: Amer Chemical Soc, 1155 16TH St, NW, Washington, DC 20036, USA. (American Chemical Society - www.acs.org; ACS Applied Materials & Interfaces - www.pubs.acs.org/journal/aamick)
Our news journalists report that additional information may be obtained by contacting T. Liu, Naton Med Grp, Naton Inst Med Technol, Beijing 100082, People's Republic of China. Additional authors for this research include Z. Zeng, Y. Liu, J. Wang, M.F. Maitz, Y. Wang, S.H. Liu, J.Y. Chen and N. Huang (see also Essential Amino Acids).
Keywords for this news article include: Asia, Lysine, Beijing, Nanoparticle, Nanotechnology, Basic Amino Acids, Diamino Amino Acids, Emerging Technologies, Essential Amino Acids, People's Republic of China
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